畜牧与兽医2024，Vol.56Issue(4)：139-146,8.
猪圆环病毒2型疫苗的应用和研发进展
Application of and research progress in porcine circovirus type 2 vaccine
摘要
Abstract
Porcine circovirus type 2(PCV2)is the major pathogen of porcine circovirus related diseases(PCVAD),which causes lym-phatic system failure and immune suppression after infection and seriously harms the normal production of the pig industry.In recent years,the research and development of PCV2 vaccine has been concerned,and relevant research has made certain progress,and a variety of vac-cines have been commercialized,including inactivated vaccines,subunit vaccines,chimeric vaccines and synthetic peptide vaccines.In ad-dition,researchers have also conducted in-depth discussions on the immune mechanism and vaccination strategy of vaccines,providing im-portant theoretical support for the development and application of vaccines.However,the current research on PCV2 vaccines still faces many challenges,such as the gradual variation of the main strain in clinical circulation from PCV2b to PCV2d,vaccine safety,long-term immune effect,etc.The immune effect of the existing vaccines still requires confirming by further studies.This article reviews the production status of PCV2 and its existing vaccines,the research on and development progress in new vaccines,the application of adjuvants in vaccines,and the protection ability of vaccines against different genotypes,in order to provide scientific reference for effective prevention and control of PCVAD in China.关键词
猪圆环病毒2型/疫苗/佐剂/保护力Key words
porcine circovirus type 2/vaccine/adjuvant/protection分类
农业科技引用本文复制引用
王鹏,沈伟桢,周斌..猪圆环病毒2型疫苗的应用和研发进展[J].畜牧与兽医,2024,56(4):139-146,8.基金项目
国家重点研发计划(2021YFD1801300) （2021YFD1801300）
