刑事技术2024，Vol.49Issue(2)：120-127,8.DOI:10.16467/j.1008-3650.2023.0036
可疑片剂中新型喹酮类物质的鉴定
Identification of New Quinazolinone in Suspected Tablets
王淑云 1胡晓强 1朱宇祥 1高慧2
作者信息
- 1. 呼和浩特市公安局禁毒支队,呼和浩特 010010
- 2. 岛津企业管理(中国)有限公司,北京 100024
- 折叠
摘要
Abstract
To study the qualitative analysis of unknown quinazolinone in suspected tablets without reference substance,the new compound discovered from a dubious package called"Huyouyou"seized by the police was tested with methaqualone standard materials and etaqualone standard materials by gas chromatography-mass spectrometry(GC-MS).The retention time of unknown compound is closed to methaqualone and etaqualone,and ion fragment m/z 235 existed both in spectrogram of methaqualone and the unknown compound.There were not any satisfying matching search results in NIST20s and new psychoactive substance(NPS)spectral library Cayman Spectral Library,and the unknown compound was suspected to be a new quinazolinone.Ultra-high performance liquid chromatography-quadrupole time-of-flight mass spectrometry(UPLC-QTOF-MS)was further used to analyze the structures of methaqualone standard materials,etaqualone standard materials and the suspected new quinazolinone.The first-grade fragment and second-grade fragment information of methaqualone standard materials and etaqualone standard materials were consistent to potentially lytic pathway.Possible molecular formula of the suspected new quinazolinone by software Formula Predictor as C16H14N2O2.According to the second-grade fragment information,the suspected new quinazolinone had a quinazolinone nucleus structure and an attached phenyl ring,but the molecular weight was 2 daltones larger than the etaqualone,suggesting a methyl moiety is replaced by oxygen.Chemical structure of the suspected new quinazolinone was predicted as 2-methyl-3-(2-methoxyphenyl)-4(3H)-quinazolinone.Nuclear magnetic resonance(NMR)was finally used to estimate the suspected molecular formula 2-methyl-3-(2-methoxyphenyl)-4(3H)-quinazolinone.1H-NMR and 13C-NMR data supported the location of the oxygen,the locations of the carbons and hydrogens were also estimated simultaneously.The chemical structure of the suspected new quinazolinone was finally verified by NMR,and the new quinazolinone was suggested to be named as methoxyqualone.关键词
法医毒物学/甲氧喹酮/超高效液相色谱-四极杆飞行时间质谱/新精神活性物质Key words
forensic toxicology/methoxyqualone/ultra-high performance liquid chromatography-quadrupole time-of-flight mass spectrometry(UPLC-QTOF-MS)/new psychoactive substance分类
社会科学引用本文复制引用
王淑云,胡晓强,朱宇祥,高慧..可疑片剂中新型喹酮类物质的鉴定[J].刑事技术,2024,49(2):120-127,8.
