中国免疫学杂志2024，Vol.40Issue(3)：503-506,4.DOI:10.3969/j.issn.1000-484X.2024.03.010
TLR4/ERK1/2信号通路在不明原因自然流产蜕膜组织中的作用研究
Role of TLR4/ERK1/2 signaling pathway in decidual tissue of unexplained spontaneous abortion
摘要
Abstract
Objective:To investigate the expression of Toll-like receptor 4(TLR4)and extracellular signal-regulated protein kinase 1/2(ERK1/2)in decidua tissue of patients with unexplained spontaneous abortion and their correlation.Methods:The expres-sions of TLR4,ERK1/2 and p-ERK1/2 in decidua tissues of 32 patients with unexplained spontaneous abortion(abortion group)and 32 normal pregnancy(control group)were detected by immunohistochemistry and Western blot,respectively.The correlation between TLR4 and p-ERK1/2 in abortion group were analyzed by Pearson hierarchical correlation analysis.Results:In immunohistochemical experiments,the cytoplasm of decidua cells in the two groups is the expression locus of TLR4,ERK1/2 and p-ERK1/2,the expression of the three proteins were different,and the expressions of TLR4 and p-ERK1/2 in abortion group were significantly higher than that in control group(P<0.01).There was no significant difference in ERK1/2 expression between abortion group and control group(P>0.05);In decidua tissue samples of abortion group,the protein level of TLR4 was higher than that of control group(P<0.05);the pro-tein level of p-ERK1/2 was significantly higher than that of control group(P<0.01),and the protein level of ERK1/2 in decidua tissue of abortion group was not statistically different from that of control group(P>0.05).TLR4 was positively correlated with p-ERK1/2 expression in abortion group(r=0.890,P<0.01).Conclusion:Abnormal activation of TLR4/ERK1/2 signaling pathway may be one of the mechanisms of unexplained spontaneous abortion.关键词
TLR4/ERK1/2/p-ERK1/2/自然流产/蜕膜Key words
TLR4/ERK1/2/p-ERK1/2/Spontaneous abortion/Decidual分类
医药卫生引用本文复制引用
李娜,栾兆进,杨美霞,宫晓玲,赵紫薇,宋芳..TLR4/ERK1/2信号通路在不明原因自然流产蜕膜组织中的作用研究[J].中国免疫学杂志,2024,40(3):503-506,4.基金项目
内蒙古自治区自然科学基金项目(2019MS08191) （2019MS08191）
内蒙古自治区高等学校科学研究项目(NJZY20175) （NJZY20175）
包头医学院科学研究基金项目(BYJJ-QM-2018005). （BYJJ-QM-2018005）
