中国免疫学杂志2024，Vol.40Issue(3)：530-533,4.DOI:10.3969/j.issn.1000-484X.2024.03.015
IL-10通过上调socs3抑制衣原体感染细胞炎症因子表达
IL-10 inhibits expression of inflammatory factors in Chlamydia-infected cells by up-regulating socs3
罗玲艳 1杜昆1
作者信息
- 1. 长江大学附属第一医院输血科,荆州 434000
- 折叠
摘要
Abstract
Objective:To investigate the role and mechanisms of SOCS3 protein in IL-10 inhibiting the expression of inflam-matory factors in Chlamydia-infected cells.Methods:The activation of STAT3 protein were examined in Chlamydia-infected cells by Western blot,and the activation of p38 and ERK1/2 were also examined in infected cells treated with socs3 siRNA.The expression of socs3 gene was examined in Chlamydia-infected cells treated with IL-10 or Stattic by RT-PCR.IL-6 and IL-12 were measured in infect-ed cells treated with socs3 siRNA using ELISA kits.Results:Socs3 expression was up-regulated by IL-10 through activation of STAT3 protein.IL-6 and IL-12 induced by Chlamydia were down-regulated by IL-10 through induction of socs3.The activation of p38 and ERK1/2 signalling pathways were inhibited by SOCS3.Conclusion:IL-10 inhibits the production of pro-inflammatory cytokines through induction of SOCS3 and inhibition p38 and ERK1/2 signalling pathways.关键词
沙眼衣原体/炎症因子/白细胞介素10/细胞因子信号转导抑制因子Key words
Chlamydia trachomatis/Inflammatory factors/IL-10/SOCS分类
医药卫生引用本文复制引用
罗玲艳,杜昆..IL-10通过上调socs3抑制衣原体感染细胞炎症因子表达[J].中国免疫学杂志,2024,40(3):530-533,4.
