CircRHOT1调节miR-187-3p/SOX4轴对乳腺癌细胞增殖、凋亡和免疫逃逸的影响OA北大核心CSTPCD
Influences of CircRHOT1 on proliferation,apoptosis and immune escape of breast cancer cells by regulating miR-187-3p/SOX4 axis
目的:研究环状RNA ras同源物基因家族成员T1(CircRHOT1)调节miR-187-3p/性别决定区Y框蛋白4(SOX4)轴对乳腺癌细胞增殖、凋亡和免疫逃逸的影响.方法:采用实时荧光定量PCR和Western blot检测体外培养的人正常乳腺上皮细胞MCF-10A和乳腺癌细胞MCF-7、Hs-578T、MDA-MB-231中CircRHOT1、miR-187-3p与SOX4表达;将体外培养的MCF-7细胞随机分为对照组、CircRHOT1…查看全部>>
Objective:To study the influences of circular RNA ras homolog family member T1(CircRHOT1)on the prolifera-tion,apoptosis and immune escape of breast cancer cells by regulating the miR-187-3p/sex-determining region Y-box protein 4(SOX4)axis.Methods:Real-time quantitative PCR and Western blot were used to detect the expressions of CircRHOT1,miR-187-3p and SOX4 in human normal breast epithelial cells MCF-10A and breast cancer cells MCF-7,Hs-578T and MDA-MB-231 …查看全部>>
孙沛;姜振伟;刘倩
武汉市普仁医院检验科,武汉 430080武汉市普仁医院检验科,武汉 430080武汉市普仁医院肿瘤科,武汉 430080
临床医学
CircRHOT1miR-187-3p/SOX4轴乳腺癌增殖凋亡免疫逃逸
CircRHOT1miR-187-3p/SOX4 axisBreast cancerProliferationApoptosisImmune escape
《中国免疫学杂志》 2024 (3)
577-585,9
湖北省卫生健康委科研项目(WJ2017F034).
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