中国免疫学杂志2024，Vol.40Issue(3)：663-667,5.DOI:10.3969/j.issn.1000-484X.2024.03.038
MicroRNA调节免疫性血小板减少症CD4+T细胞亚群免疫功能的研究进展
Research progress of microRNA-mediated immune function of CD4+T cells subsets in immune thrombocytopenia
摘要
Abstract
MicroRNA(miRNA)is a kind of small non-coding single stranded RNA that can participate in multiple biological processes.It also plays an important role in regulating the immune function of the body.Immune thrombocytopenia(ITP)is an autoim-mune disease,whose cause and deterioration are closely related to miRNA regulates immune function of CD4+T cells subsets.In ITP patients,different expression of miRNA can affect the immune function of CD4+T cells subsets,which causes not only unbalanced ex-pression of Th1/Th2,Th17/Treg and excessive differentiation of TFH,but also abnormal cytokine secretion furthermore.This paper summarizes the unbalanced mechanism of miRNA regulating immune function of CD4+T cells subsets in ITP,so as to provide inspira-tion for exploring the immunology and immunotherapy of ITP.关键词
MicroRNA/免疫性血小板减少症/CD4+T细胞亚群Key words
MicroRNA/Immune thrombocytopenia/CD4+T cells subsets分类
医药卫生引用本文复制引用
宋辉,郭一慧,许家威,曾清,程纬民..MicroRNA调节免疫性血小板减少症CD4+T细胞亚群免疫功能的研究进展[J].中国免疫学杂志,2024,40(3):663-667,5.基金项目
广西自然科学基金项目(2018GXNSFAA281082) （2018GXNSFAA281082）
广西中医药大学强基计划项目(XYJB074). （XYJB074）
