中国实用外科杂志2024，Vol.44Issue(3)：335-340,345,7.DOI:10.19538/j.cjps.issn1005-2208.2024.03.20
早期三阴性乳腺癌CPS、TILs水平及其对新辅助治疗疗效预测价值研究
An exploratory study on CPS and TILs expression levels in early-stage triple-negative breast cancer and their predictive value for neoadjuvant therapy response
摘要
Abstract
Objective To investigate the programmed cell death ligand-1(PD-L1)combined positive score(CPS)and tumor infiltrating lymphocytes(TILs)levels in early-stage triple-negative breast cancer(TNBC),and to explore their predictive value for neoadjuvant therapy response.Methods The clinicopathological data and follow-up information of early-stage triple-negative breast cancer patients who received neoadjuvant therapy in Peking University First Hospital during January 2016 to December 2019 were retrospectively analyzed.A total of 2183 newly diagnosed early breast cancer patients were treated,of which 259(11.9％)had TNBC.Fifty-seven patients were included in the study.DAKO murine anti-human monoclonal antibody(clone number:22C3)was used as the test kit to detect CPS,and TILs percentage was evaluated in accordance with the procedure recommended by the TILs International Working Group Breast Cancer Evaluation Guidelines.Define CPS≥l0 as positive CPS and TILs＞10％as moderate to high level.Results There were 26 patients(45.6％)with positive CPS and 38 patients(66.7％)with moderate to high level of TILs,of which 24 cases had both positive CPS and moderate to high level of TILs.There was a significant correlation between positive CPS and moderate to high level of TILs(P＜0.001).Twelve patients(21％)achieved pathological complete response(pCR)after neoadjuvant therapy.There were 9 patients(34.6％),11(28.9％)and 8 patients(33.3％)with positive CPS,moderate to high level of TILs,and both positive CPS and moderate to high level of TILs achieved pCR after neoadjuvant therapy.Logistic multivariate analysis showed that CPS≥10 was significantly associated with pCR after neoadjuvant therapy(P=0.042).The median follow-up time was 48.5 months.Multivariate COX regression analysis showed that lymph node positive(P=0.002)and TILs＞30％(P=0.038)were independent prognostic factors affecting 3-year recurrence-free survival rate.Conclusion Nearly half of TNBC patients had both positive CPS and moderate to high level of TILs,and there was a significant correlation between CPS and TILs levels,both of which had predictive value for pCR and prognosis after neoadjuvant therapy.关键词
三阴性乳腺癌/新辅助治疗/程序性死亡配体-1/综合阳性评分/肿瘤浸润淋巴细胞/病理完全缓解/预后Key words
triple-negative breast cancer/neoadjuvant therapy/programmed death receptor ligand-1(PD-L1)/combined positive score(CPS)/tumor infiltrating lymphocytes(TILs)/pathological complete response/prognosis分类
医药卫生引用本文复制引用
周思成,段学宁,熊焰,刘荫华,梁丽,李东,辛灵,向泓雨,程元甲,刘倩,徐玲,叶京明..早期三阴性乳腺癌CPS、TILs水平及其对新辅助治疗疗效预测价值研究[J].中国实用外科杂志,2024,44(3):335-340,345,7.基金项目
中国青年乳腺外科医生基金项目(No.2020-CHPASLP-01,No.CJBSRAF-2022) （No.2020-CHPASLP-01,No.CJBSRAF-2022）
北京医学奖励基金会项目(No.YXJL-2020-0941-0736) （No.YXJL-2020-0941-0736）
北京康盟慈善基金会项目 （）
