中国医药科学2024，Vol.14Issue(5)：177-180,194,5.DOI:10.20116/j.issn2095-0616.2024.05.41
CHA2DS2-VASc评分联合LVEF预测慢性心力衰竭合并永久性心房颤动患者发生认知功能障碍的价值
The value of CHA2DS2-VASc scores combined with LVEF in predicting cognitive impairment in patients with chronic heart failure and permanent atrial fibrillation
摘要
Abstract
Objective To explore the value of score for atrial fibrillation recurrence risk score(CHA2DS2-VASc)combined with left ventricular ejection fraction(LVEF)in predicting cognitive impairment in patients with chronic heart failure and permanent atrial fibrillation.Methods A retrospective analysis was conducted on the data of 299 patients with chronic heart failure combined with permanent atrial fibrillation admitted to Zhengzhou Central Hospital from December 2019 to December 2021.The patients were divided into a cognitive impairment group and a normal cognitive function group based on the presence of cognitive impairment.The value of CHA2DS2-VASc scores combined with LVEF in predicting cognitive impairment in patients with chronic heart failure and permanent atrial fibrillation was analyzed.Results The gender,education level,smoking history,diabetes,stroke and NYHA classification composition ratio of the cognitive impairment group were significantly different from those of the normal cognitive function group(P<0.05).The age,CHA2DS2-VASc scores,N-terminal pro-brain natriuretic peptide(NT-proBNP)of the cognitive impairment group were higher than those of the normal cognitive function group(P<0.05).Systolic pressure and LVEF of the cognitive impairment group were lower than those of the normal cognitive function group(P<0.05).Age,education level,LVEF,NT-proBNP,and CHA2DS2-VASc scores were independent risk factors for cognitive impairment in patients with chronic heart failure and permanent atrial fibrillation(P<0.05).The CHA2DS2-VASc scores in patients with chronic heart failure combined with permanent atrial fibrillation were negatively correlated with LVEF(r=-0.417,P=0.000).The best cutoff points for predicting cognitive impairment in patients with chronic heart failure and permanent atrial fibrillation using CHA2DS2-VASc scores and LVEF were 4 points and 43%,respectively.The sensitivity,specificity,and AUC of the combination of the two were 82.43%,96.03%,and 0.930,respectively.Conclusion LVEF and CHA2DS2-VASc scores are independent risk factors for cognitive impairment in patients with chronic heart failure and permanent atrial fibrillation.Both of them can serve as reference indicators for predicting cognitive impairment in patients,and the combination of the two has a higher value in prediction.关键词
CHA2DS2-VASc评分/左心室射血分数/永久性心房颤动/慢性心力衰竭/认知功能障碍Key words
CHA2DS2-VASc scores/Left ventricular ejection fraction/Permanent atrial fibrillation/Chronic heart failure/Cognitive impairment分类
医药卫生引用本文复制引用
栗若泰,赵建华,张世云..CHA2DS2-VASc评分联合LVEF预测慢性心力衰竭合并永久性心房颤动患者发生认知功能障碍的价值[J].中国医药科学,2024,14(5):177-180,194,5.基金项目
河南省二〇一八年科技发展计划(182300410389) （182300410389）
河南省医学科技攻关计划(联合共建)项目(LHGJ20190436). （联合共建）
