中国斜视与小儿眼科杂志2024，Vol.32Issue(1)：1-4,后插16,5.DOI:10.3969/J.ISSN.1005-328X.2024.01.001
基于孟德尔随机化研究探讨电脑使用时间与近视的因果关系
Investigation of the causal relationship between time spent on computer and myopia based on a Mendelian randomization
摘要
Abstract
Objective The two-sample Mendelian randomization method(MR)was used to investigate the causal relationship between time spent on computer and myopia.Methods The pooled data from gene-wide association studies(GWAS)were analysed.Genetic loci closely associated with myopia were collected as instrumental variables.Two-sample Mendelian randomization was performed by inverse variance weighting method,weighted median and Mr-Egger,respectively.Inverse variance weighting method,Mr-Egger and leave-one-out were used to test heterogeneity and sensitivity.Mr-Egger was used for pleiotropic analysis.Results The Inverse variance weighting method showed significant positive correlation between time spent on computer and myopia,with the odds ratio of 1.041[95％ confidence interval,CI):1.023～1.060;P=5.69e-06].Weighted median and Mr-Egger showed similar causality.The result of Mr-Egger indicated the absence of pleiotropy.Conclusions There is a positive relationship between time spent on computer and myopia.关键词
电脑/近视/孟德尔随机化Key words
Computer/Myopia/Mendelian randomization引用本文复制引用
刘楠,李莉,樊云葳,刘雯,刘曦,郑凌方,王家文..基于孟德尔随机化研究探讨电脑使用时间与近视的因果关系[J].中国斜视与小儿眼科杂志,2024,32(1):1-4,后插16,5.基金项目
国家自然科学基金资助(编号:81970844) （编号:81970844）
