中国医药科学2024，Vol.14Issue(5)：42-45,4.DOI:10.20116/j.issn2095-0616.2024.05.09
NLRP3炎症小体在眼科疾病的研究进展
Research progress of NLRP3 inflammasome in ophthalmic diseases
摘要
Abstract
The NLRP3 proteome in the NOD-like receptor family is an important component of the innate immune system,which can be activated by various stimuli,including ion fluence,mitochondrial dysfunction,production of reactive oxygen species,and lysosomal damage.They mediate the activation of cysteine-containing aspartate proteolytic enzyme-1(caspase-1)and the secretion of the pro-inflammatory cytokine interleukin-1β(IL-1β)and interleukin-18(IL-18),leading to various cell death.In ophthalmic diseases,the pathogenesis and activation mode of many diseases are not yet clear,but through the research and exploration of NLRP3 inflammasome,the pathogenesis and mechanism of age-related macular degeneration,diabetic retinopathy,dry eye,glaucoma,and other diseases are clearer.This article reviews the biological characteristics and activation and regulatory mechanisms of NLRP3 inflammasomes,their relationship with related eye diseases,and the latest research status.关键词
NLRP3/眼科疾病/含半胱氨酸的天冬氨酸蛋白水解酶-1/白细胞介素-1βKey words
NLRP3/Ophthalmic diseases/Caspase-1/Interleukin-1β分类
医药卫生引用本文复制引用
许嘉洋,张天资,樊世超..NLRP3炎症小体在眼科疾病的研究进展[J].中国医药科学,2024,14(5):42-45,4.基金项目
内蒙古自治区卫生健康科技计划项目(202201471). （202201471）
