中国医药科学2024，Vol.14Issue(5)：111-114,4.DOI:10.20116/j.issn2095-0616.2024.05.25
基于网络药理学探讨平阳益心饮治疗射血分数保留型心力衰竭的作用机制
Exploration of the mechanism of action of Pingyang Yixin Decoction in the treatment of heart failure with preserved ejection fraction based on network pharmacology
摘要
Abstract
Objective To predict the potential targets and pathways of Pingyang Yixin Decoction in the treatment of heart failure with preserved ejection fraction(HFpEF)based on network pharmacology methods.Methods Based on the HERB database and the SwissTarget Prediction data platform,the component targets of Pingyang Yixin Decoction were predicted.HFpEF targets were obtained through the OMIM database,PhamGKB database,and GeneCards database.Venny 2.1.0 was used to select the intersection of drug and disease targets,and Cytoscape was used to construct a"component-disease target"network for protein-protein interaction network(PPI).The core target of Pingyang Yixin Decoction for treating HFpEF was obtained through network topology analysis,and the core target was used for gene ontology(GO)and Kyoto encyclopedia of genes and genomes(KEGG)through the Metascape database.Results Through the method of network pharmacology,524 potential targets were identified for the treatment of HFpEF with Pingyang Yixin Decoction,which mainly participated in biological processes such as cell response to nitrogen compounds,regulation of systemic processes,positive regulation of circulatory processes and phosphorylation.It was involved in regulating 235 pathways including cancer-related pathways,cGMP PKG signaling pathway,cAMP signaling pathway,lipid,and atherosclerosis.Conclusion Pingyang Yixin Decoction can participate in cell apoptosis and proliferation through multiple components,targets,and pathways,thus achieving the goal of treating HFpEF.关键词
网络药理学/平阳益心饮/射血分数保留型心力衰竭/分子机制Key words
Network pharmacology/Pingyang Yixin Decoction/Heart failure with preserved ejection fraction/Molecular mechanism分类
医药卫生引用本文复制引用
汤嘉慧,王新东,董其美..基于网络药理学探讨平阳益心饮治疗射血分数保留型心力衰竭的作用机制[J].中国医药科学,2024,14(5):111-114,4.基金项目
董其美全国名老中医药专家传承工作室建设项目(国中医药人教函[2022]75号) （国中医药人教函[2022]75号）
江苏省研究生科研与实践创新计划(SJCX22_0859). （SJCX22_0859）
