肿瘤防治研究2024，Vol.51Issue(3)：163-168,6.DOI:10.3971/j.issn.1000-8578.2024.23.1041
膀胱癌组织中MIS18BP1的表达及临床意义
Expression and Clinical Significance of MIS18BP1 in Bladder Cancer Tissues
摘要
Abstract
Objective To explore the expression,correlation with clinicopathologic parameters,and clinical significance of MIS18 binding protein 1(MIS18BP1)in bladder cancer.Methods TCGA and GEO data-bases were used to analyze the mRNA expression of MIS18BP1 in tumors and controls,and the results were verified via qRT-PCR.UALCAN online database was utilized in the analysis of the expression of MIS18BP1 and its correlation with clinicopathological parameters and the degree of immune cell infiltration.Immun-ohistochemistry was employed to analyze the expression of MIS18BP1 in bladder cancer and its relationship with clinicopathological features.The ROC curve was applied to evaluate the diagnostic value of MIS18BP1 mRNA in bladder cancer.Results Bioinformatics analysis and qRT-PCR results revealed the increased expression of MIS18BP1 mRNA in bladder cancer compared with that in the control group(P＜0.05).Immunohistochemistry unveiled the significantly high positive rate of MIS18BP1 protein in bladder cancer(P＜0.05)and its correlation with the clinical stage of tumors,depth of invasion,and lymph node metastasis(P＜0.05).The immune infiltration analysis showed the association of MIS18BP1 with immune cell infil-tration in bladder cancer.Conclusion The increased expression level of MIS18BP1 gene and protein in bladder cancer may regulate the development of bladder cancer by influencing immune cell infiltration.关键词
膀胱癌/MIS18BP1/TCGA数据库/GEO数据库/qRT-PCR/免疫组织化学Key words
Bladder cancer/MIS18BP1/TCGA database/GEO database/qRT-PCR/Immunohistochemistry分类
医药卫生引用本文复制引用
曹文静,汪煜琳,翟雨晴,张宗亮,原江水,宋卫青..膀胱癌组织中MIS18BP1的表达及临床意义[J].肿瘤防治研究,2024,51(3):163-168,6.基金项目
National Natural Science Foundation of China(No.31971191) 国家自然科学基金(31971191) （No.31971191）
