肿瘤防治研究2024，Vol.51Issue(3)：185-190,6.DOI:10.3971/j.issn.1000-8578.2024.23.0997
外周血T淋巴细胞亚群与接受卡瑞利珠单抗治疗的晚期非小细胞肺癌患者预后的关系
Relationship Between Peripheral Blood T Lymphocyte Subsets and Prognosis of Patients with Advanced Non-small Cell Lung Cancer Treated with Camrelizumab
摘要
Abstract
Objective To explore the relationship between peripheral blood T lymphocyte subsets and prognosis of patients with advanced non-small cell lung cancer(NSCLC)who received treatment with camrelizumab.Methods We retrospectively collected data from 88 patients with advanced NSCLC who underwent camrelizumab treatment.Peripheral blood lymphocyte subsets were collected from patients before and two months after treatment.Kaplan-Meier curves and Cox regression analysis were employed to inves-tigate the relationship between peripheral blood T lymphocyte subsets and PFS and OS.Results Compared with non-responder group,the baseline peripheral blood CD4+/CD8+ratio was higher(P=0.038),while the CD8+T lymphocyte percentage was lower(P=0.036)in the responder group.Kaplan-Meier curves showed that a high baseline CD4+/CD8+ratio was associated with long PFS and OS(P=0.001,P=0.023).Multivar-iate Cox analysis revealed that the baseline CD4+/CD8+ratio was a significant predictor for PFS and OS.Additionally,a high post-treatment CD4+/CD8+ratio and high CD4+T lymphocyte percentage were associated with long PFS(P=0.005,P=0.015),whereas a low post-treatment CD8+T lymphocyte percentage was associated with long PFS and OS(P=0.001,P=0.016).Conclusion The peripheral blood CD4+/CD8+ratio can serve as a predictive factor for survival of patients with NSCLC treated with camrelizumab.关键词
非小细胞肺癌/CD4+/CD8+比值/CD4+T淋巴细胞/CD8+T淋巴细胞/抗PD-1治疗/卡瑞利珠单抗Key words
Non-small cell lung cancer/CD4+/CD8+ratio/CD4+T cell/CD8+T cell/Anti-PD-1 immunotherapy/Camrelizumab分类
医药卫生引用本文复制引用
董长鸿,封岩,江艳婷,高洁,蒋晓东..外周血T淋巴细胞亚群与接受卡瑞利珠单抗治疗的晚期非小细胞肺癌患者预后的关系[J].肿瘤防治研究,2024,51(3):185-190,6.基金项目
Postgraduate Research & Practice Innovation Program of Jiangsu Province(No.SJCX23_1415) （No.SJCX23_1415）
Social Developmental Project of Jiangsu Province(No.BE2017648) 江苏省研究生科研与实践创新计划(SJCX23 1415) （No.BE2017648）
江苏省重点研发计划(BE2017648) （BE2017648）
