肿瘤防治研究2024，Vol.51Issue(3)：195-202,8.DOI:10.3971/j.issn.1000-8578.2024.23.0888
非小细胞肺癌微卫星(GT/CA)n重复序列多态性的研究进展
Progress of Microsatellite(GT/CA)n Repeat Polymorphisms in Non-small Cell Lung Cancer
摘要
Abstract
Non-small cell lung cancer(NSCLC)is the most important histological type of lung cancer.This disease affects a large number of patients,and the prognosis of advanced patients is poor.Although great progress has been achieved for existing treatment methods,challenges still exist.Cancer is a genetic disease,and its occurrence is accompanied by substantial genomic-sequence instability.(GT/CA)n repeat sequence is a common microsatellite sequence serving as transcriptional function-related regions,DNA-methylation modification sites,and other functional sites.Its polymorphism is closely related to the expression of EGFR,HO-1,and HIF-1α in NSCLC patients.(GT/CA)n repeat sequence is the breakthrough point to explore the molecular mechanism of NSCLC occurrence and development,develop molecular markers for diagnosis and prognosis and epigenetics research.This paper summarizes the studies on(GT/CA)n repeat polymorphisms in NSCLC with the aim of providing references for relevant NSCLC research.关键词
非小细胞肺癌/微卫星/(GT/CA)n重复序列/EGFRKey words
NSCLC/Microsatellite/(GT/CA)n repeat sequence/EGFR分类
医药卫生引用本文复制引用
杨汶峻,傅雨婷,袁叶琴,刘达,蒋斌元..非小细胞肺癌微卫星(GT/CA)n重复序列多态性的研究进展[J].肿瘤防治研究,2024,51(3):195-202,8.基金项目
Youth Program of National Natural Science Foundation of China(No.81802952) （No.81802952）
Scientific research project of Hunan Provincial Department of Education(No.21B0411) （No.21B0411）
Changsha Central Hospital Scientific Research Project(No.YNKY202201) 国家自然科学基金青年科学基金(81802952) （No.YNKY202201）
湖南省教育厅科学研究项目(21B0411) （21B0411）
长沙市中心医院科学研究项目(YNKY202201) （YNKY202201）
