非小细胞肺癌微卫星(GT/CA)n重复序列多态性的研究进展OA北大核心CSTPCD
Progress of Microsatellite(GT/CA)n Repeat Polymorphisms in Non-small Cell Lung Cancer
非小细胞肺癌(NSCLC)是肺癌最主要的组织学类型,患者数量庞大且晚期患者疗效差,现有治疗手段虽取得巨大进展但仍面临挑战.肿瘤的发生伴随大量基因组序列的不稳定,(GT/CA)n重复序列是一种常见的微卫星序列,参与了基因转录和DNA甲基化等调控过程.现有研究表明,NSCLC中(GT/CA)n重复序列的多态性与EGFR、HO-1和HIF-1α基因的表达密切相关,可作为探索NSCLC发生发展的分子机制、开发诊疗预后分子标志物及相关表观遗传学研究的切入点.本文总结了NSCLC中微卫星(GT/CA)n重复多态性的相关研究,希望能为NSCLC的相关研究提供参考.
Non-small cell lung cancer(NSCLC)is the most important histological type of lung cancer.This disease affects a large number of patients,and the prognosis of advanced patients is poor.Although great progress has been achieved for existing treatment methods,challenges still exist.Cancer is a genetic disease,and its occurrence is accompanied by substantial genomic-sequence instability.(GT/CA)n repeat sequence is a common microsatellite sequence serving as transcriptional function-related regions,DNA-methylation modification sites,and other functional sites.Its polymorphism is closely related to the expression of EGFR,HO-1,and HIF-1α in NSCLC patients.(GT/CA)n repeat sequence is the breakthrough point to explore the molecular mechanism of NSCLC occurrence and development,develop molecular markers for diagnosis and prognosis and epigenetics research.This paper summarizes the studies on(GT/CA)n repeat polymorphisms in NSCLC with the aim of providing references for relevant NSCLC research.
杨汶峻;傅雨婷;袁叶琴;刘达;蒋斌元
410004 长沙,南华大学衡阳医学院附属长沙中心医院检验科||410004 长沙,南华大学衡阳医学院附属长沙中心医院中心实验室410004 长沙,南华大学衡阳医学院附属长沙中心医院呼吸与危重症医学科
临床医学
非小细胞肺癌微卫星(GT/CA)n重复序列EGFR
NSCLCMicrosatellite(GT/CA)n repeat sequenceEGFR
《肿瘤防治研究》 2024 (003)
195-202 / 8
Youth Program of National Natural Science Foundation of China(No.81802952);Scientific research project of Hunan Provincial Department of Education(No.21B0411);Changsha Central Hospital Scientific Research Project(No.YNKY202201) 国家自然科学基金青年科学基金(81802952);湖南省教育厅科学研究项目(21B0411);长沙市中心医院科学研究项目(YNKY202201)
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