肿瘤防治研究2024，Vol.51Issue(3)：210-215,6.DOI:10.3971/j.issn.1000-8578.2024.23.0734
胶质瘤位点特异性分布的相关因素探讨
Factors Associated with Site-specific Distribution of Glioblastoma
李雯婷 1暴洪博 1梁鹏1
作者信息
- 1. 150081 哈尔滨,哈尔滨医科大学附属肿瘤医院神经外科
- 折叠
摘要
Abstract
The treatment of glioblastoma,the most prevalent malignant tumor in the central nervous system,poses considerable challenges.Glioblastoma multiforme,classified as a grade Ⅳ highly malignant brain glioma by the World Health Organization,is typically managed through a combination of surgery,postoperative chemotherapy,and radiotherapy.The treatment of glioblastoma is complicated by its infiltrative nature,genetic heterogeneity,and presence of the blood-brain barrier.Almost all cases of glioblastoma experience recurrence despite aggressive therapy,exploring the development of updated molecular treatment strategies that can improve overall efficacy.A crucial aspect in modern neurosurgery is the precise delineation of brain regions in terms of their anatomy and function.It serves as the fundamental basis for investigating variations in the distribution of brain gliomas.Hence,this review will elucidate the origin of glioblastomas and analyze the potential factors contributing to the spatially specific distribution of gliomas on the basis of a theoretical framework of brain connectomics research.Molecular characteristics,information pathways,tumor microenvironment landscape,and immunology will inform the analysis.We aim to identify novel biomolecular targets and therapeutic pathways to gain scientific insights for effective glioblastoma treatment.关键词
胶质瘤/解剖/空间分布/分子特征Key words
Glioma/Anatomy/Spatial distribution/Molecular feature分类
医药卫生引用本文复制引用
李雯婷,暴洪博,梁鹏..胶质瘤位点特异性分布的相关因素探讨[J].肿瘤防治研究,2024,51(3):210-215,6.
