中医肿瘤学杂志2024，Vol.6Issue(2)：33-41,9.DOI:10.19811/j.cnki.ISSN2096-6628.2024.03.005
槐耳颗粒联合免疫治疗用于晚期三阴性乳腺癌解救治疗的临床分析
Clinical Analysis on Huaier Granules Combined with Immunotherapy for Rescue Treatment of Advanced Triple-Negative Breast Cancer
摘要
Abstract
Objective To explore the clinical benefit and safety of Huaier Granules combined with immunotherapy for rescue treatment of advanced triple-negative breast cancer(TNBC).Methods A retrospective analysis was conducted on 67 advanced TNBC patients with positive PD-L1 expression treated at Cangzhou Central Hospital from November 2019 to December 2021.Patients were divided into the control group(n = 33)and the observation group(n = 34)based on the treatment regimens received.The control group received the treatment regimen of camrelizumab and albumin-bound paclitaxel,while the observation group additionally received Huaier Granules.Clinical efficacy,changes of Karnofsky performance status(KPS)score,levels of tumor biomarker,levels of T lymphocyte subset,prognosis,and adverse reactions were compared after treatment between the two groups.Results After treatment,the observation group exhibited higher disease control rate compared with the control group(73.53％vs 48.48％),and KPS score enhancing rate also improved(52.94％vs 15.15％).The proportions of CD4+ T lymphocytes and CD4+/CD8+ in the observation group were higher than those in the control group,and the proportion of CD8+ T lymphocytes was lower than that in the control group. Median progression-free survival(PFS) of the observation group was longer than the control group[13.41 months(95％ CI:11.62,15.19) vs 9.53 months (95％ CI: 7.76, 11.30)], and median overall survival(OS) of the observation group was also longer than the control group [16.38 months(95％ CI:14.51,18.25) vs 12.02 months(95％ CI:10.52,13.51)]. The incidences of thrombocytopenia and immune- related pneumonia in the observation group were lower than the control group. The above differences were statistically significant(P<0.05). Conclusion Huaier Granules combined with immunotherapy for rescue treatment of advanced TNBC shows great clinical efficacy,improves the quality of life and the prognosis of patients,and has good safety.关键词
槐耳颗粒/免疫治疗/三阴性乳腺癌/解救治疗/预后Key words
Huaier Granules/immunotherapy/triple-negative breast cancer/rescue treatment/prognosis分类
医药卫生引用本文复制引用
殷雨来,赵春智,张嘉澍,张晓宇..槐耳颗粒联合免疫治疗用于晚期三阴性乳腺癌解救治疗的临床分析[J].中医肿瘤学杂志,2024,6(2):33-41,9.基金项目
沧州市科技计划项目(编号:222106141) （编号:222106141）
河北省医学科学研究课题(编号:20220400) （编号:20220400）
河北省中医药科研计划项目(编号:2020521). （编号:2020521）
