中国中西医结合杂志2024，Vol.44Issue(3)：290-295,6.DOI:10.7661/j.cjim.20230724.020
夏枯草开音合剂改善早期喉癌激光术后嗓音及生活质量随机对照研究
Kaiyin Mixture of Spica prunellae Improves the Voice and Quality of Life after Laser Surgery for Early Glottic Laryngeal Carcinoma:A Randomized Controlled Trial
摘要
Abstract
Objective To observe the effect of Kaiyin Mixture of Spica prunellae on voice and quality of life of patients with early glottic laryngeal cancer after CO2 laser surgery.Methods A total of 52 patients with stage T1a glottic laryngeal carcinoma who visited Shanghai First People's Hospital from September 2019 to June 2021 were randomly assigned to treatment group(26 cases)and control group(26 cases)according to random number.Both groups received type Ⅲ-Ⅴa CO2 laser,the treatment group received Kaiyin Mixture of Spica prunellae,and the control group received placebo,each taking a course of treatment(3 months),supplemented by voice training,and followed up for 6 months.The voice acoustic analysis,voice handicap index and Quality of Life Scale were collected at 1,3 and 6 months after operation for observation and comparison.Results There was no significant difference in the indicators between two groups at 1 month after surgery(P＞0.05).At 3 months after surgery,the normalized noise energy(NNE),harmonics to noise ratio(NHR)and the scores in the"physiological"category of the voice handicap index(VHI)scale of the treatment group,were better than those of the control group(P＜0.05).At 6 months after surgery,the data of Jitter,Shimmer,NNE,HNR,VHI scale and quality of life score of the treatment group were better than those of the control group(P＜0.05).Conclusion Kaiyin Mixture of Spica prunellae could improve the voice and quality of life of patients with early glottic laryngeal cancer after CO2 laser surgery.关键词
T1a期声门型喉癌/夏枯草开音合剂/嗓音/生活质量/中药/中西医结合Key words
T1a glottic laryngeal carcinoma/Kaiyin mixture of Spica prunellae/voice/quality of life/Chinese herbal medicine/integrative medicine引用本文复制引用
龚姝婧,孙臻峰,罗丹,丁健,董频,王丽华,郭裕..夏枯草开音合剂改善早期喉癌激光术后嗓音及生活质量随机对照研究[J].中国中西医结合杂志,2024,44(3):290-295,6.基金项目
上海市进一步加快中医药事业发展三年行动计划[No.ZY(2018-2010)-FWTX-3021] （2018-2010）
