中国中西医结合杂志2024，Vol.44Issue(3)：309-315,7.DOI:10.7661/j.cjim.20240115.002
IgA肾病中医证型与黏膜免疫相关性横断面研究
Cross-sectional Study on the Correlation Between Chinese Medicine Syndrome Types and Mucosal Immunity in IgA Nephropathy
摘要
Abstract
Objective To explore the Chinese medicine(CM)syndrome classification and its correlation with mucosal immunity in patients with IgA nephropathy(IgAN).Methods A cross-sectional study was performed,including 410 patients with IgAN.The data of CM syndrome were collected,and the CM syndrome classification was summarized by factor analysis and cluster analysis.Serum levels of galactose-deficient IgA1(Gd-IgA1)and mucosal immune-related markers,including B cell activating factor(BAFF),a proliferation inducing ligand(APRIL),interleukin-6(IL-6)and tumor necrosis factor-α(TNF-α)were measured in 118 patients.The correlation between serum Gd-IgA1 levels in different CM syndromes and these mucosal immune-related markers was analyzed.Results A total of 51 symptoms,tongue images and pulse images closely related to IgAN syndromes were collected,and 13 common factors with eigenvalues greater than 1 could be extracted,which could be clustered into 4 categories.The CM syndromes of IgAN patients were classified as Fei-Pi qi-deficiency syndrome in 186 cases(45.36％),Gan-Shen yin-deficiency syndrome in 102 cases(24.88％),Pi-Shen yang-deficiency syndrome in 79 cases(19.27％),and Gan qi depression syndrome in 43 cases(10.49％).The serum Gd-IgA1 levels of patients with Fei-Pi qi-deficiency syndrome was 6.09(4.44,7.00)µg/mL,which was significantly higher than that of patients with other CM syndromes(P＜0.01).Gd-IgA1 levels were elevated in patients with IgAN at different sites of mucosal inflammation compared with patients without mucosal inflammation(P＜0.01).Serum Gd-IgA1 levels in IgAN patients demonstrated correlations with mucosal immune-related markers APRIL,IL-6 and TNF-α(P＜0.05).Conclusions The prevalent clinical CM syndromes in IgAN patients are Fei-Pi qi-deficiency syndrome,Gan-Shen yin deficiency syndrome,Pi-Shen yang-deficiency syndrome,and Gan qi depression syndrome.Fei-Pi qi-deficiency syndrome is most closely associated with abnormal mucosal immunity in IgAN.关键词
IgA肾病/中医证候/黏膜免疫/低半乳糖基化lgA1/中西医结合Key words
IgA nephropathy/Chinese medicine syndrome/mucosal immunity/Galactose-deficient IgA1/integrative medicine引用本文复制引用
成庭柱,任翼,杜亚婷,冯雪,孙士鹏,饶向荣,李深..IgA肾病中医证型与黏膜免疫相关性横断面研究[J].中国中西医结合杂志,2024,44(3):309-315,7.基金项目
国家自然科学基金资助项目(No.81573791) （No.81573791）
北京市科学技术委员会首都临床特色应用研究(No.Z181100001718123) （No.Z181100001718123）
