安徽中医药大学学报2024，Vol.43Issue(2)：19-24,6.DOI:10.3969/j.issn.2095-7246.2024.02.006
开心散治疗乳腺癌失眠症患者的临床疗效及对血清5-羟色胺水平的影响
Clinical Effect of Kaixin Powder in Treatment of Breast Cancer Patients with Insomnia and Its Effect on the Serum Level of 5-Hydroxytryptamine
摘要
Abstract
Objective To investigate the clinical effect of Kaixin Powder in the treatment of breast cancer patients with insom-nia and its effect on the serum level of 5-hydroxytryptamine(5-HT).Methods A total of 63 breast cancer patients with in-somnia were randomly divided into treatment group with 30 patients and control group with 33 patients.The patients in the con-trol group were given oral administration of estazolam,and those in the treatment group were given Kaixin Powder combined with estazolam.The two groups were compared in terms of Pittsburgh sleep quality index(PSQI),Self-rating Depression Scale(SDS),Self-rating Anxiety Scale(SAS),European Organization for Research and Treatment of Cancer-Quality of Life Ques-tionnaire-Core 30(EORTC QLQ-C30),and serum 5-HT level before and after treatment,and after treatment for 4 consecutive weeks,the two groups were compared in terms of clinical outcome and the incidence rate of adverse reactions.Results After 4 weeks of treatment,both groups had significant reductions in PSQI,SDS,and SAS scores(P＜0.05),and the treatment group had a significantly lower PSQI score than the control group(P＜0.05);compared with the control group,the treatment group had significantly higher scores of physical function,emotional function,cognitive function,and social function in EORTC QLQ-C30(P＜0.05);after treatment,both groups had a significant increase in the serum level of 5-HT(P＜0.05),and the treat-ment group had a significantly higher serum level of 5-HT than the control group(P＜0.05).Compared with the control group,the treatment group had a significantly better clinical outcome(P＜0.05)and a significantly lower incidence rate of adverse re-actions(P＜0.05).Conclusion Compared with estazolam alone for patients with breast cancer,Kaixin Powder combined with estazolam can better alleviate insomnia,increase the serum level of 5-HT,improve quality of life,and reduce the incidence rate of adverse reactions.关键词
开心散/失眠症/乳腺癌/5-羟色胺Key words
Kaixin Powder/Insomnia/Breast cancer/5-Hydroxytryptamine分类
医药卫生引用本文复制引用
张浩,朱国旗,杨绍杰,任扩军,马小鹏,张雨,祝永福..开心散治疗乳腺癌失眠症患者的临床疗效及对血清5-羟色胺水平的影响[J].安徽中医药大学学报,2024,43(2):19-24,6.基金项目
安徽中医药大学2022年高校科研项目(2022AH050415) （2022AH050415）
安徽中医药大学科研基金项目(2021yfylc44) （2021yfylc44）
2021年安徽省重点研究与开发计划人口健康专项(202104j7020004) （202104j7020004）
