电针激活Nrf2/HO-1通路抗帕金森病模型小鼠氧化应激的机制研究OACSTPCD
Mechanism of Electroacupuncture Against Oxidative Stress in a Mouse Model of Parkinson's Disease by Activating the Nuclear Factor Erythroid 2-related Factor 2/Heme Oxygenase-1 Path-way
目的 观察电针"风府""太冲""足三里"穴对帕金森病(Parkinson's disease,PD)模型小鼠大脑纹状体中酪氨酸羟化酶(tyrosine hydroxylase,TH)、核因子E2 相关因子 2(nuclear factor-erythroid 2-related factor 2,Nrf2)、血红素加氧酶-1(heme oxygenase-1,HO-1)水平的影响,探讨电针治疗 PD的可能机制.方法 将 30 只小鼠按随机数字表法…查看全部>>
Objective To investigate the effect of electroacupuncture at Fengfu,Taichong,and Zusanli points on the levels of tyrosine hydroxylase(TH),nuclear factor erythroid 2-related factor 2(Nrf2),and heme oxygenase-1(HO-1)in the corpus striatum of mice with Parkinson's disease(PD),as well as the possible mechanism of electroacupuncture in the treatment of PD.Methods A total of 30 mice were divided into control group,model group,and electroacupuncture group using a r…查看全部>>
包小立;李媛媛;汪瑶;王彦春
湖北中医药大学针灸骨伤学院,湖北 武汉 430065湖北中医药大学针灸骨伤学院,湖北 武汉 430065湖北中医药大学针灸骨伤学院,湖北 武汉 430065湖北中医药大学中医临床学院,湖北 武汉 430065
临床医学
帕金森病Nrf2/HO-1通路氧化应激电针
Parkinson's diseaseElectroacupunctureNuclear factor erythroid 2-related factor 2/heme oxygenase-1 pathwayOxidative stress
《安徽中医药大学学报》 2024 (2)
内质网应激在帕金森病模型大鼠中的作用及针刺干预的调控机制研究
32-37,6
国家自然科学基金项目(81473788)
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