基于"脾虚生痰,痰瘀互结"理论探讨健脾化痰祛瘀调节内质网应激治疗动脉粥样硬化OA

Atherosclerosis is a chronic inflammatory change in which lipid deposition forms atherosclerotic plaques in blood vessel walls and leads to vascular wall thickening and lumen stenosis.It is closely related to cardiovascular and cerebrovascular diseases and is the main cause of high mor-tality and disability.Studies have found that atherosclerosis is closely related to endoplasmic reticulum stress.Stimulating factors such as ischemia re-perfusion,oxidative stress,and overload of lipid and cholesterol can cause the disorder of endoplasmic reticulum,thus inducing endoplasmic reticu-lum stress.The persistence of endoplasmic reticulum stress can further induce cell apoptosis and promote the occurrence and development of athero-sclerosis.According to the theory of traditional Chinese medicine,the spleen is not healthy,the phlegm is endogenous,the blood stasis is generated over time,and the phlegm and blood stasis are obstructed in the vein,leading to atherosclerosis.Therefore,based on the theory of spleen-deficiency generating phlegm and interconnecting phlegm and blood stasis,this paper discusses the treatment of atherosclerosis by strengthening spleen,elimi-nating phlegm and removing blood stasis,regulating endoplasmic reticulum stress,and provides a new idea for the clinical application of traditional Chinese medicine to prevent and treat atherosclerosis.