成都中医药大学学报2024，Vol.47Issue(2)：18-22,5.DOI:10.13593/j.cnki.51-1501/r.2024.02.018
胆巴浸泡附子的工艺研究
Process of Soaking Fuzi in Solution of Danba
摘要
Abstract
Objective:To explore the effect of Danba soaking process on aconite alkaloids in the processing of Fuzi,and determine the best process parameters.Methods:A single factor investigation was carried out from the three aspects of the concentration of the Dan-ba aqueous solution,the soaking time of the Fuzi in the Danba aqueous solution,and the solid-liquid ratio of the aconite and the Danba aqueous solution.The HPLC method was used to determine the content of the Fuzi according to the ＂Chinese Pharmacopoeia＂2020 e-dition.The alkaloid content in the aconite was determined,and the change of the alkaloid content in the aconite was analyzed.Re-sults:The content of diester alkaloids in Fuzi showed a general downward trend with the prolongation of bile infusion time,the decrease of the solid-liquid ratio of bile solution and the increase of the concentration of bile solution;the content of monoester alkaloids had no obvious change;The total alkaloid content showed a downward trend.Based on the morphology and alkaloid content of Fuzi,the best process for soaking Danba was determined to be 35%-40%Danba aqueous solution concentration,and the aconite soaked at a solid-liquid ratio of 1∶2 for no less than 20 days.Conclusion:Danba soaking can effectively preserve Fuzi and reduce the content of its toxic components,diester-type alkaloids.The optimal soaking process can provide a reference for the processing of Fuzi in Danba.关键词
附子/胆巴/浸泡工艺/生物碱/含量测定Key words
Fuzi/Danba/Soaking process/Alkaloids/Content determination分类
医药卫生引用本文复制引用
郑琪,何成军,刘杰,耿昭,邱波,蒙春旺,周勤梅..胆巴浸泡附子的工艺研究[J].成都中医药大学学报,2024,47(2):18-22,5.基金项目
国家自然科学基金项目(82104546) （82104546）
