风湿病与关节炎2024，Vol.13Issue(3)：7-12,6.DOI:10.3969/j.issn.2095-4174.2024.03.002
类风湿关节炎合并焦虑抑郁患者中医证型分布及与凝血指标相关性分析
Analysis of the Correlation Between Distribution of TCM Syndrome Types and Coagulation Indicators in Patients with Rheumatoid Arthritis Combined with Anxiety and Depression
摘要
Abstract
Objective:To explore the distribution characteristics of traditional Chinese medicine(TCM)syndrome types in patients with rheumatoid arthritis(RA)combined with anxiety and depression,and analyze their correlation with coagulation indicators.Methods:One hundred RA patients with anxiety and depression were screened,and the general information,anxiety and depression scores(SAS,SDS),inflammatory indicators(ESR,CRP),DAS28,the levels of coagulation indicators(PLT,PT,INR,APTT,TT,FIB,DD,FDP)of each group were compared.Pearson was used to analyze the correlation between SAS,SDS,and coagulation indicators.Results:① According to the levels of anxiety and depression,the mild anxiety and depression were mainly characterized by damp heat obstruction syndrome and phlegm stasis obstruction syndrome;the moderate and severe characterized by liver and kidney deficiency syndrome.② Among the four syndrome types,the PLT level of phlegm stasis obstruction syndrome was higher than that of cold dampness obstruction syndrome and damp heat obstruction syndrome(P<0.05);the PT of damp heat obstruction syndrome and liver kidney deficiency syndrome was higher than that of phlegm stasis obstruction syndrome(P<0.05).③ Correlation analysis found that in damp heat obstruction syndrome,SAS and SDS score were positively correlated with FDP and negatively correlated with PT,APTT,and TT;in cold dampness obstruction syndrome,SAS score was positively correlated with DD,while SDS score was positively correlated with PLT;in phlegm stasis obstruction syndrome,there is a positive correlation between SAS score and DD;in liver and kidney deficiency syndrome,SAS score is positively correlated with PLT and negatively correlated with PT and APTT,and SDS score is positively correlated with PLT,FIB,DD and negatively correlated with PT.Conclusion:The coagulation index levels in patients with rheumatoid arthritis combined with anxiety and depression are related to different TCM syndrome types.Clinical practice should be combined with the method of promoting blood circulation and removing stasis based on syndrome differentiation and treatment.关键词
类风湿关节炎/焦虑抑郁/凝血指标/中医证型/相关性分析Key words
rheumatoid arthritis/anxiety and depression/coagulation indicators/TCM syndrome types/correlation analysis引用本文复制引用
赵会,赵鸿芳,王淼,朱艳..类风湿关节炎合并焦虑抑郁患者中医证型分布及与凝血指标相关性分析[J].风湿病与关节炎,2024,13(3):7-12,6.基金项目
国家自然科学基金项目(81403484) （81403484）
安徽省高校自然科学基金项目(KJ2019A0448) （KJ2019A0448）
安徽省临床医学研究中心项目(安徽省科技厅皖社科[2020]41 号) （安徽省科技厅皖社科[2020]41 号）
安徽中医药大学临床科研项目(2021efylc07) （2021efylc07）
安徽省中医药传承创新科研项目(2020ccyb13) （2020ccyb13）
