风湿病与关节炎2024，Vol.13Issue(4)：7-11,17,6.DOI:10.3969/j.issn.2095-4174.2024.04.002
基于数据挖掘的中医药治疗原发性干燥综合征燥湿互结证的用药规律研究
A Study on the Medication Rules of TCM Treating Primary Sjögren's Syndrome with the Combination of Dryness and Dampness Based on Data Mining
摘要
Abstract
Objective:To summarize the medication rules of the research team in the Rheumatology Department of Dongfang Hospital,Beijing University of Chinese Medicine in the treatment of primary Sjögren's syndrome with the combination of dryness and dampness.Methods:The medical records of patients with primary Sjögren's syndrome with the combination of dryness and dampness from January 2018 to December 2022 were screened.A database was established using software Excel and statistics were conducted.Software Modeler 18.0 was used for analysis of association rules and complex network,and the results were visualized using software Cytoscape.Cluster analysis was conducted using the software SPSS 20.0.Results:A total of 139 prescriptions were included,involving 188 Chinese medicines.A total of 34 Chinese medicines were used with a frequency equal or more than 25 times.Seventy-three drug association combinations were screened out,and complex network analysis resulted in the core Chinese medicine combination:Danshen(Radix et Rhizoma Salviae Miltiorrhizae)-Qinghao(Herba Artemisiae Annuae)-Shihu(Caulis Dendrobii)-Baishao(Radix Paeoniae Alba),and 8 cluster combinations.Conclusion:The clinical medication for primary Sjögren's syndrome with the combination of dryness and dampness is based on the methods of clearing dampness and heat,removing blood stasis and generating fluids,modifying according to the different degrees of"dampness""heat""dryness"and"blood stasis",which provides ideas and references in clinic.关键词
原发性干燥综合征/数据挖掘/用药规律/关联分析/中医药Key words
primary Sjögren's synd-rome/data mining/medication rules/associa-tion analysis/traditional Chinese medicine引用本文复制引用
李媛,杜梦梦,茹尘,李乐晴,卢斯仪,刘小平,朱跃兰,侯秀娟..基于数据挖掘的中医药治疗原发性干燥综合征燥湿互结证的用药规律研究[J].风湿病与关节炎,2024,13(4):7-11,17,6.基金项目
国家自然科学基金面上项目(8187150396) （8187150396）
