广东药科大学学报2024，Vol.40Issue(2)：83-90,8.DOI:10.16809/j.cnki.2096-3653.2023102604
Eudragit RS 30D修饰的冰片缓释微囊的制备与评价
Preparation and evaluation of borneol sustained-released microcapsules modified by Eudragit RS 30D
摘要
Abstract
Objective To study the optimal process for preparing borneol microcapsules with sodium alginate and Eudragit RS 30D(SA/RS 30D/BN MCs),and carry out related characterization.Methods The SA/RS 30D/BN MCs was prepared by complex coacervation method.The effects of mass concentrations of borneol,soluble starch,Tween 80,sodium alginate(SA)solution,Eudragit RS 30D and CaCl2 solution on the quality of microcapsules were investigated by the single factor method with encapsulation rate and drug loading capacity as the assessment indicators.Then,the optimal formulation was screened by L9(34)orthogonal test with the encapsulation rate as the assessment indicator.The appearance,physical and chemical properties,in vitro release behavior,preliminary stability of the optimal formulation was evaluated.Results The optimal of SA/RS 30D/BN MCs was as follows:borneol,soluble starch,Tween 80,sodium alginate,Eudragit RS 30D,CaCl2 with mass concentrations of 3.33%,0.17%,0.17%,1.00%,5.00%,1.50%,respectively.The average encapsulation rate was(94.18±0.47)%and the drug loading was(30.42±0.17)%.In the preliminary stability test,the retention rate of borneol in the microcapsules reached 92.2%,and the characterization results showed that borneol microcapsules with sustained release performance were successfully prepared.Conclusion The borneol microcapsules prepared by complex coacervation method with sodium alginate and Eudragit RS 30D as composite capsules can significantly improve the stability of borneol and have a certain sustained release effect.关键词
Eudragit RS 30D/海藻酸钠/冰片/复凝聚法/微囊/缓释制剂Key words
Eudragit RS 30D/sodium alginate/borneol/complex coacervation/microcapsules/sustained release分类
医药卫生引用本文复制引用
方淑冰,林琳,邓彩怡,黄华,陈媛,高皓诗,郭波红..Eudragit RS 30D修饰的冰片缓释微囊的制备与评价[J].广东药科大学学报,2024,40(2):83-90,8.基金项目
国家自然科学基金项目(82304413) （82304413）
广东药科大学"创新强校工程"资助项目[广东省大学生创新创业训练计划(202310573036)] （202310573036）
