混合磨玻璃结节实性成分的CT定量参数对肺腺癌组织分化的预测价值OACSTPCD

To explore the predictive value of three-dimensional CT quantitative parameters of solid component of mixed ground glass nodules in differentiation of lung invasive adenocarcinoma(IAC).The clinical and imaging data of 99 patients with IAC confirmed by pathology after operation was retrospectively analyzed.According to the grading system of the International Association for the Study of Lung Cancer Pathology Committee,highly differentiated IAC(53 cases),moderately differentiated IAC(31 cases),poorly differentiated IAC(15 cases).The correlation between three-dimensional CT quantitative parameters of solid component and the degree of differentiation in IAC was observed.The results showed that the volume,volume percentage,mean CT value and average diameter of solid component had statistically significant differences among three groups(P＜0.001).The results of multiple comparison showed that the volume,volume percentage,mean CT value and average diameter of the solid component in poorly differentiated I AC were higher than those in other two groups.However,the volume percentage between moderately differentiated IAC and highly differentiated IAC was statistically significant.The highly differentiated IAC and the moderately differentiated IAC were included in group A.and the poorly differentiated IAC was included in group B.The ROC curve for predicting poorly differentiated IAC showed that the cut-off values of the volume,volume percentage,mean CT value and average diameter of solid component were 341.5 mm3,52.9％,-116.5 HU,9.65 mm.The three-dimensional CT quantitative parameters of the solid component of mGGN have a high predictive value for the degree of differentiation,the guiding significance for making a diagnosis and giving treatment and judging the prognosis are obtained.