分析测试学报2024，Vol.43Issue(4)：649-653,5.DOI:10.12452/j.fxcsxb.23111102
高效液相色谱-蒸发光散射法测定化妆品中二硬脂基二甲基氯化铵
Determination of Distearyl Dimethyl Ammonium Chloride in Cosmet-ics by High Performance Liquid Chromatography-Evaporative Light Scattering Detector
摘要
Abstract
A method for the analysis of distearyl dimethyl ammonium chloride(DSDMAC)in various types of cosmetics was established based on high performance liquid chromatography-evaporative light scattering detector(HPLC-ELSD).Cosmetics were dispersed with acetonitrile aqueous solution(volume ratio 2∶1)and extracted by sodium chloride with oscillation under the oscillation frequency of 160 r/min for 30 minutes.After extraction,the samples were eluted by gradient elution using ace-tonitrile and 100 mmol/L ammonium acetate aqueous solution(pH 5.5)as the mobile phases,with an AcclaimTM Surfactant column(150 mm×4.6 mm,5 μm).DSDMAC analysis could be completed within 18 min.The external standard method was applied for quantitative determination.The method showed a good linear relationship for DSDMAC in the concentration range of 10-200 mg/L,with the correlation coefficient(r2)as 0.999 4.The limits of detection(LOD)and quantitation(LOQ)were 3.27 mg/kg and 9.96 mg/kg,respectively.The average recoveries in makeup remover oil,hair care essential oil,eye-shadow,pancake,toothpaste,lipstick,emulsion,shampoo,essence water and mouthwash were from 82.5%to 101%,with the relative standard deviations(RSDs,n=6)not ex-ceeded 6.3%.This method was applied to 133 commercial samples,and the content of DSDMAC in one positive emulsion exceeded the regulatory requirement.With good precision and accuracy,the developed method was suitable for the quantitative analysis of DSDMAC in typical kinds of cosmetics,which could provide technical support for the quality and safety monitoring of cosmetics.关键词
化妆品/二硬脂基二甲基氯化铵/高效液相色谱/蒸发光散射Key words
cosmetics/distearyl dimethyl ammonium chloride/high performance liquid chroma-tography/evaporative light scattering分类
化学化工引用本文复制引用
汤娟,丁友超,费晓庆,吴斌,钱志娟,陈山丹,李柏..高效液相色谱-蒸发光散射法测定化妆品中二硬脂基二甲基氯化铵[J].分析测试学报,2024,43(4):649-653,5.基金项目
海关总署科研项目(2022HK028) （2022HK028）
