胰腺实性假乳头状肿瘤的临床特征OA

Objective:Solid pseudopapillary tumor of the pancreas is a rare low-grade malignant tumor with no typical symptoms and signs,making preoperative diagnosis difficult.This study aims to summarize the clinical characteristics of solid pseudopapillary tumors of the pancreas and discuss its diagnostic methods and treatment principles. Methods:A total of 42 patients diagnosed with solid pseudopapillary tumors of the pancreas by pathological examination following surgical treatment at the First Hospital of Shanxi Medical University from January 2010 to May 2023 were selected.Their demographic,radiological,pathological characteristics,and clinical treatment modalities were retrospectively analyzed. Results:Among the 42 patients,there were 12 males and 30 females,mainly presenting with gastrointestinal symptoms.The preoperative diagnosis included 22 patients with solid pseudopapillary tumor of the pancreas,1 pancreatic cancer,3 mucinous cystadenoma,1 sarcoma,1 non-functional pancreatic islet cell tumor,2 neuroendocrine tumor,and the rest were unclear.The diagnostic accuracy of CT and magnetic resonance imaging(MRI)in preoperative imaging examinations was significantly higher than that of two-dimensional ultrasonography.Among tumor markers,elevated levels of neuron-specific enolase(NSE)were most common(8 patients),which may have diagnostic value for solid pseudopapillary tumors of the pancreas.Immunohistochemical detection showed positive rates of β-catenin,vimentin,α1-antitrypsin(AAT),cluster of differentiation 10(CD10),synaptophysin(SYN)and NSE were 100%,93%,86%,82%,78%,and 66%,respectively.Among the 42 follow-up patients,6 patients were lost to follow-up,and the remaining 36 were followed up for a median of 49.83(25.00 to 104.53)months,including 1 patient experienced tumor recurrence and metastasis 4 years after surgery and died 2 months later,1 patient experienced recurred 2 years after surgery,and the remaining 34 patients survived without tumor recurrence or metastasis. Conclusion:Solid pseudopapillary tumors of the pancreas predominantly affects females,and presents mainly with gastrointestinal symptoms.CT and MRI exhibit high diagnostic accuracy,while a definitive diagnosis requires microscopic observation and immunohistochemistry.Surgical treatment is an effective treatment.