临床与病理杂志2024，Vol.44Issue(1)：31-37,7.DOI:10.11817/j.issn.2095-6959.2024.230447
结直肠腺癌中COL9A1蛋白的表达及其临床意义
Protein expression of COL9A1 in colorectal adenocarcinoma and its clinical significance
摘要
Abstract
Objective:To investigate the expression of collagen type Ⅸ alpha 1 chain(COL9A1)in the microenvironment of colorectal adenocarcinoma and its correlation with tumor progression and clinical significance. Methods:A total of 408 specimens of surgically resected colorectal adenocarcinoma collected from January 2012 to January 2021 were included.The expression of COL9A1 in colorectal cancer and adjacent normal tissues was detected by immunohistochemistry.The expression of tumor protein 53(P53)and mismatch repair(MMR)proteins MLH1,MSH2,MSH6 and PMS2 in tumor tissues was also examined.The correlation between COL9A1 expression and various clinicopathological parameters,as well as with P53 mutation and MMR status,was statistically analyzed.The prognosis of patients with positive COL9A1 expression was also analyzed. Results:The expression level of COL9A1 in colorectal adenocarcinoma was significantly lower than that in adjacent normal tissues(P<0.001).The expression level of COL9A1 was associated with tumor infiltration depth,clinical stage,and mesenteric lymph node metastasis(χ2=16.943,χ2=89.031,and χ2=84.814,all P<0.001),but not with P53 mutation or MMR status(χ2=0.677 or χ2=1.260,both P>0.05).The Log-rank test showed that patients with negative expression of COL9A1 had significantly lower progression-free survival(PFS)and overall survival(OS)compared to patients with positive COL9A1 expression(P<0.001 and P=0.040,respectively). Conclusion:Loss of COL9A1 protein expression in colorectal adenocarcinoma is closely related to tumor infiltration and metastasis,indicating poor prognosis.This suggests that COL9A1 may serve as a potential molecular marker and therapeutic target for prognosis evaluation and drug selection in colorectal cancer.关键词
Ⅸ型胶原α1/结直肠腺癌/临床病理/预后Key words
collagen type Ⅸ alpha 1 chain/colorectal adenocarcinoma/clinicopathology/prognosis引用本文复制引用
李幸子,龚进,甘柳,李爽,吴雪辉..结直肠腺癌中COL9A1蛋白的表达及其临床意义[J].临床与病理杂志,2024,44(1):31-37,7.基金项目
国家中医药管理局中药药理科研三级实验室开放基金(2023PTCM14),宜昌市医疗卫生科研项目(A21-2-022).This work was supported by the Open Fund for the Third Level Laboratory of Traditional Chinese Medicine Pharmacology Research of the State Administration of Traditional Chinese Medicine(2023PTCM14)and the Yichang Medical and Health Research Project(A21-2-022),China. （2023PTCM14）
