广州医药2024，Vol.55Issue(3)：213-220,230,9.DOI:10.3969/j.issn.1000-8535.2024.03.001
肿瘤可塑性与药物治疗抵抗
Tumor Plasticity and Therapeutic Resistance
摘要
Abstract
Drug therapy resistance has emerged as a primary cause of treatment failure in cancer management.Recent research indicates that the resistance of tumor cells may stem from their high degree of intracellular heterogeneity,with the underlying basis being tumor plasticity.Tumor cell plasticity can trigger a cascade of responses,including the development of resistance to treatment,evasion of the immune system,and invasion and metastasis into surrounding tissues and the vascular system.This article provides a brief overview of the manifestations of tumor cell plasticity and its non-genetic adaptive mechanisms in drug therapy resistance,along with novel strategies for targeted treatment.关键词
肿瘤可塑性/药物治疗抵抗/肿瘤异质性/治疗新策略Key words
tumor plasticity/drug therapy resistance/tumor heterogeneity/novel treatment strategies引用本文复制引用
何丹,成炜,刘铭..肿瘤可塑性与药物治疗抵抗[J].广州医药,2024,55(3):213-220,230,9.基金项目
国家自然科学基金(82122048,82003773,82203380) （82122048,82003773,82203380）
广东省基础与应用基础研究基金(2023A1515011416) （2023A1515011416）
