临床与病理杂志2024，Vol.44Issue(1)：87-95,9.DOI:10.11817/j.issn.2095-6959.2024.230345
细胞焦亡及其相关因子caspase-1和IL-1β与非小细胞肺癌
Cell pyroptosis and related factors caspase-1,IL-1β,and non-small cell lung cancer
摘要
Abstract
Cell pyroptosis is a programmed cell death process associated with inflammation,which occurs after mediation by caspase-1 and the pro-inflammatory factor interleukin1β(IL-1β),exerting a dual role in promoting or inhibiting the occurrence and development of non-small cell lung cancer(NSCLC).On the one hand,pyroptosis and related factors contribute to the progression of NSCLC by building a pro-tumor microenvironment.On the other hand,caspase-1 and IL-1β delay NSCLC progression by regulating the classical inflammatory pyroptosis pathway.In terms of lung tumor treatment,although some chemotherapy,immunotherapy,targeted therapy,and Chinese medicine therapy enhance drug sensitivity through the regulation of cell pyroptosis molecular mechanisms,delaying the progression of cancer cells,the surrounding normal tissues are also damaged due to adverse reactions caused by cell pyroptosis.To explore the role of caspase-1 and IL-1β as novel,independent biomarkers in the occurrence and treatment of NSCLC by inducing pyroptosis,and to provide a new theoretical basis and strategy for the targeted treatment of NSCLC.关键词
非小细胞肺癌/细胞焦亡/半胱天冬氨酸蛋白酶-1/白细胞介素-1βKey words
non-small cell lung cancer/pyroptosis/caspase-1/interleukin 1β引用本文复制引用
王金霞,雷丰丰..细胞焦亡及其相关因子caspase-1和IL-1β与非小细胞肺癌[J].临床与病理杂志,2024,44(1):87-95,9.基金项目
国家自然科学基金(41961016).This work was supported by the National Natural Science Foundation of China(41961016). （41961016）
