广州医药2024，Vol.55Issue(3)：316-323,8.DOI:10.3969/j.issn.1000-8535.2024.03.017
GDM患者妊娠中期血糖异常项数及妊娠晚期血糖指标与妊娠结局的关系
The association between abnormal blood glucose items,blood glucose levels and pregnancy outcome in women with gestational diabetes mellitus
摘要
Abstract
Objective To investigate the relationship between abnormal blood glucose items in the 75 g oral glucose tolerance test(OGTT)at 24-28 weeks of pregnancy and the blood glucose levels before delivery in the third trimester of pregnancy and pregnancy outcomes in gestational disbetes mellitus(GDM)patients.Methods All 167 GDM patients diagnosed at 24-28 weeks of gestation in Women and Children's Medical Center Affiliated to Guangzhou Medical University from November 2019 to May 2020 were enrolled as subjects.The pregnant women with only 1 abnormal blood glucose item among the 75 g OGTT results were classified as GDMⅠ group(92 cases),with 2 abnormal items were GDMⅡ group(48 cases),and with 3 abnormal items were GDMⅢ group(27 cases).The demographic characteristics of the three groups of GDM patients were compared.The relationship between the general demographic characteristics of GDM patients and the mean value of blood glucose monitoring before delivery in the third trimester was analyzed,and the influence of blood glucose monitoring on adverse pregnancy outcomes was also analyzed.Results ①With different BMI and HbA1c,there were significant differences in 75 g OGTT blood glucose items(P<0.05).BMI level had statistically significant effects on fasting blood glucose,1-hour postprandial blood glucose and 2-hour postprandial blood glucose in the third gestational trimester(P<0.05).②With different number of abnormal blood glucose items,there were significant in fasting blood glucose and 2 hours postprandial blood glucose(P<0.05).③There were statistically significant differences in the outcomes of neonatal hypoglycemia,premature rupture of membranes and preterm delivery in different fasting blood glucose groups(P<0.05).There were statistically significant differences in neonatal hypoglycemia and premature rupture of membranes between different 2 hours postprandial blood glucose(P<0.05).Conclusions BMI can affect the blood glucose screening results of 75g OGTT in the second trimester.The more abnormal blood glucose items in the 75g OGTT test,the greater the probability of adverse pregnancy outcome.Standardized exercise diet intervention and necessary drug intervention during pregnancy can improve the HbA1c level in the third trimester.关键词
妊娠期糖尿病/糖化血红蛋白/血糖异常/妊娠结局Key words
gestational diabetes/glycated hemoglobin/abnormal blood glucose/pregnant outcome引用本文复制引用
唐国一,杨红梅,杨恺欣,曾慧倩,曹晓旭..GDM患者妊娠中期血糖异常项数及妊娠晚期血糖指标与妊娠结局的关系[J].广州医药,2024,55(3):316-323,8.基金项目
广州市基础研究计划市校(院)联合资助项目(2023A03J0873) （院）
