单孔胸腔镜下肺段及肺叶切除术治疗早期肺癌的临床效果OACSTPCD

Objective To investigate the clinical efficacy of single-incision thoracoscopic segmentectomy and lobectomy for early-stage lung cancer and its impact on surgical indicators and lung function in patients.Methods A retrospective analysis was conducted on the clinical data of 106 patients with early-stage lung cancer admitted to the Eighth Affiliated Hospital of Xinjiang Medical University from September 2020 to March 2023.The patients were assigned to the segmentectomy group(n=53)and the lobectomy group(n=53)following the different surgical methods.Both groups of patients were treated with single-incision thoracoscopic surgery.The surgical indicators,lung function indicators,immune function indicators,and incidence of complications were compared between the two groups.Results The intraoperative blood loss and postoper-ative drainage volume in the segmentectomy group were lower than those in the lobectomy group;while the length of hospi-tal stay was shorter in the segmentectomy group;the operation time was longer in the segmentectomy group,all with statis-tical significance(P<0.05).No significant difference was observed in the number of lymph node dissections and lymph node stations between the two groups(P>0.05).No significant difference was found in the forced expiratory volume in 1 second(FEV1)and forced vital capacity(FVC)levels before surgery between the two groups(P>0.05).The FEV1 and FVC levels of both groups were lower than before surgery at 1 month after surgery,but the segmentectomy group was high-er than the lobectomy group,and the differences were statistically significant(P<0.05).No significant difference was found in the levels of CD3+,CD4+,and CD4+/CD8+ before surgery between the two groups(P>0.05).The levels of CD3+ and CD4+ were higher,and the level of CD4+/CD8+ was lower than before surgery at 3 days after surgery in both groups.The CD3+ and CD4+ levels in the segmentectomy group were significantly higher than those in the lobectomy group(P<0.05).No significant difference was found in the CD4+/CD8+ levels at 3 days after surgery between the two groups(P>0.05).The difference in the incidence of complications during hospitalization between the lobectomy group and the segmentectomy group was not statistically significant(13.21%vs.7.55%;P>0.05).Conclusion Compared with single-incision thoracoscopic lobectomy for early-stage lung cancer,single-incision thoracoscopic segmentectomy can significantly reduce intraoperative blood loss and postoperative drainage volume,shorten the length of hospital stay,and achieve marked therapeutic effects.It also promotes postoperative lung function and immune function in patients,with a high safety profile.