保健医学研究与实践2024，Vol.21Issue(1)：132-138,7.DOI:10.11986/j.issn.1673-873X.2024.01.22
脂氧合酶在前列腺癌中的作用研究进展
Research progress on the role of lipoxygenase in prostate cancer
摘要
Abstract
Prostate cancer is a common disease in middle-aged and elderly men.Studies have shown that the lipoxygenase(LOX)pathway plays an important role in its occurrence,development,invasion,and metastasis,and can serve as a new target for its pre-vention and treatment.LOX mainly includes 5-LOX,12-LOX,15-LOX-1,and 15-LOX-2,among which 5-LOX and 12-LOX pro-mote the occurrence,development,invasion,and metastasis of prostate cancer.Although 15-LOX-1 promotes prostate cancer,it plays a key role in the anti-prostate cancer process of docosahexaenoic acid(DHA).15-LOX-2 has an inhibitory effect on prostate cancer.This article comprehensively reviews the role and mechanism of LOX in prostate cancer,aiming to provide a reference for the prevention and treatment of prostate cancer.关键词
脂氧合酶/前列腺癌/5-脂氧合酶/12-脂氧合酶/15-脂氧合酶Key words
Lipoxygenase/Prostate cancer/5-lipoxygenase/12-lipoxygenase/15-lipoxygenase分类
医药卫生引用本文复制引用
叶娟,吴杰,徐春梅,杨睿,晏琼,干飞,刘国珍..脂氧合酶在前列腺癌中的作用研究进展[J].保健医学研究与实践,2024,21(1):132-138,7.基金项目
国家重点研发计划项目(2020YFC2006000) （2020YFC2006000）
湖北省武汉市卫生计生委科研计划资助项目(WX18D26). （WX18D26）
