广东药科大学学报2024，Vol.40Issue(2)：63-69,7.DOI:10.16809/j.cnki.2096-3653.2023120802
基于溶剂峰压制与OPLS-DA法分析小儿止咳糖浆成分差异
Study on the differences in constituents of Xiao'er Zhike Tangjiang based on solvent peaks suppression combined with OPLS-DA method
摘要
Abstract
ed:Objective To study the differences in the constituents of Xiao'er Zhike Tangjiang between different enterprises by solvent peaks suppression and OPLS-DA analysis,and carry out effective differentiation and identification.Methods After segmenting and integrating the hydrogen spectra of 34 samples from 21 production batches from 6 enterprises,OPLS-DA method was used to analyze the spectra.Results The H spectra of Xiao'er Zhike Tangjiang from the six enterprises were similar,however the little contents were different after solvent peaks suppression.The results of two experiments were analyzed by OPLS-DA method,which indicated that the contents were different among different manufacturers.Conclusion An effective method could distinguish Xiao'er Zhike Tangjiang from different manufacturers by 1H-NMR fingerprint and OPLS-DA analysis,which provides a new method for the quality standard of Xiao'er Zhike Tangjiang.关键词
小儿止咳糖浆/成分差异/溶剂峰压制/OPLS-DA识别模式Key words
Xiao'er Zhike Tangjiang/the differences of constituents/solvent peaks suppression/orthogonal partial least squares analysis分类
医药卫生引用本文复制引用
郑晓红,高荣敏,肖志会..基于溶剂峰压制与OPLS-DA法分析小儿止咳糖浆成分差异[J].广东药科大学学报,2024,40(2):63-69,7.基金项目
2021年度中国科学院技术支撑人才项目(2022006) （2022006）
