子宫内膜异位症相关生物标志物研究进展OACSTPCD
Research progress on biomarkers related to endometriosis
子宫内膜异位症(EMs)其特征是子宫腔外存在子宫内膜样组织,是育龄期妇女常见的一种慢性良性易复发疾病,全球发病率约为 10%.由于该病是一种多因素疾病,发病机制未阐明,目前诊断金标准仍为腹腔镜病理检查,临床上缺少敏感且特异的生物标志物,寻找准确可靠、适用于临床的无创生物标志物是当前研究的热点和重点.本文对与EMs相关的糖类蛋白、转录组学、自身抗体生物标志物中最重要、最新颖的研究结果进行总结,为早期诊断、靶向治疗提供新的策略.
Endometriosis(EMs),characterized by the presence of endometrioid tissue outside the uterine cavity,is a common chronic benign recurrent disease in women of childbearing age,with a global incidence rate of about 10%.Due to its multifactorial nature and unclear pathogenesis,the current diagnostic gold standard for this dis-ease is still laparoscopic pathology.There is a lack of sensitive and specific biomarkers in clinical practice.Find-ing accurate,reliable,and applicable non-invasive biomarkers is currently a hot topic and focus of research.This article summarizes the most important and novel research results of EMs-related glycoproteins,transcriptomics,and autoantibody biomarkers,and provides new strategies for early diagnosis and targeted therapy.
黄静瑶;刘俐伶
右江民族医学院研究生学院,百色 533000广西壮族自治区人民医院生殖医学与遗传中心,南宁 530021
临床医学
子宫内膜异位症生物标志物糖类蛋白转录组学自身抗体
endometriosisbiomarkersglycoproteinstranscriptomicsautoantibody
《广西医科大学学报》 2024 (003)
458-463 / 6
广西自然科学基金青年基金(No.2018GXNSFBA138047)
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