广西医科大学学报2024，Vol.41Issue(3)：464-470,7.DOI:10.16190/j.cnki.45-1211/r.2024.03.020
外泌体调控肺癌肿瘤微环境机制和临床应用的研究进展
Advancements in the study of exosome-mediated regulation mechanisms of the tumor micro-environment and its clinical applications in lung cancer
摘要
Abstract
The incidence of lung cancer is increasing year by year,and it is currently the leading cause of cancer-related deaths.Exosomes are endogenous membrane vesicles secreted by cells,and have been recognized as es-sential carriers of intercellular genetic materials,playing a bridging role in communication between different cells.In recent years,a growing body of research data have indicated that exosomes carrying genetic materials such as proteins,lipids,and nucleic acids(including lncRNA,microRNA,mRNA)play a significant role in the tumor microenvironment of lung cancer.This article mainly reviews the mechanisms of exosomes regulating the tumor microenvironment in lung cancer,and discusses the application value of exosomes as drug delivery vehi-cles and circulating biomarkers in the diagnosis and treatment evaluation of lung cancer.关键词
外泌体/肺癌/肿瘤微环境/临床应用Key words
exosome/lung cancer/tumor microenvironment/clinical application分类
医药卫生引用本文复制引用
刘超,裴圣林..外泌体调控肺癌肿瘤微环境机制和临床应用的研究进展[J].广西医科大学学报,2024,41(3):464-470,7.基金项目
广西医疗卫生适宜技术开发与推广应用项目资助(No.S2019043) （No.S2019043）
