河南中医2024，Vol.44Issue(4)：503-508,6.DOI:10.16367/j.issn.1003-5028.2024.04.0094
理中汤加减治疗非酒精性脂肪性肝病临床研究
Clinical Study on Modified Middle-Regulating Decoction in the Treatment of Non-Alcoholic Fatty Liver Disease
摘要
Abstract
Objective:To observe the clinical efficacy of Modified Middle-Regulating Decoction on non-alcoholic fatty liver disease(NAFLD).Methods:A total of 110 patients with NAFLD were randomly divided into the observation group and the control group,with 55 cases in each group.The control group was given polyene phosphatidylcholine for treatment,while the observation group was given Modified Middle-Regulating Decoction on the basis of the control group.The liver function indexes[including alanine aminotransferase(ALT),aspartate aminotransferase(AST),glutamine transpeptidase(GGT)],blood lipid indexes[including total cholesterol(CHOL),triglyceride(TG),low density lipoprotein(LDL-C)],blood glucose indexes[including fasting blood glucose(FBG),fasting insulin(FINS),hemoglobin A1c(HbA1c),insulin resistance index(HOMA-IR)],liver stiffness measurement(LSM),controlled at-tenuation parameter(CAP)and TCM syndrome scores were compared between the two groups before and after treatment.Results:The effective rate of the observation group was 85.45%,higher than that of the control group(54.55%)(P<0.05).After treatment,the levels of ALT,AST and GGT in the two groups were lower than those before treatment,and the above indexes in the observation group were lower than those in the control group(P<0.05);the levels of FBG,HOMA-IR,FINS and HbA1c in the two groups were lower than those before treatment,and the levels of FBG and HOMA-IR in the observation group were lower than those in the control group(P<0.05),and there were no statistically significant differences in the levels of FINS and HbA1c in the observation group compared with the control group(P>0.05);the levels of CHOL,TG and LDL-C in the two groups were lower than those before treatment,and the above indexes in the observation group were lower than those in the control group(P<0.05);the levels of LSM and CAP in the two groups were lower than those before treatment,and the level of CAP in the observation group was lower than that in the control group(P<0.05),and there was no statistically significant difference in the level of LSM in the observation group compared with the control group(P>0.05);the syndrome scores of TCM in the two groups were lower than those before treatment,and the syndrome scores of TCM in the observation group were lower than those in the control group(P<0.05).Conclusion:Middle-Regulating Decoction for NAFLD can effectively improve the patients'liver function indexes,blood lipid levels and insulin resistance,relieve clinical symptoms and improve quality of life.关键词
非酒精性脂肪性肝病/理中汤/多烯磷脂酰胆碱/中西医结合疗法/《伤寒论》/张仲景Key words
non-alcoholic fatty liver disease(NAFLD)/Middle-Regulating Decoction/polyene phosphatidylcholine/integrated traditional Chinese and western medicine therapy/Treatise on Gold Damage/Zhang Zhongjing分类
医药卫生引用本文复制引用
王月明,李泽鹏,周晓玲,沈新辉..理中汤加减治疗非酒精性脂肪性肝病临床研究[J].河南中医,2024,44(4):503-508,6.基金项目
广西壮族自治区自然科学基金青年基金项目(2020GXNSFBA297133) （2020GXNSFBA297133）
广西壮族自治区中医药管理局自筹课题项目(GZZC2020417) （GZZC2020417）
柳州市应用技术研究与开发计划项目(2018AF10503) （2018AF10503）
