基础医学与临床2024，Vol.44Issue(4)：533-538,6.DOI:10.16352/j.issn.1001-6325.2024.04.0533
嗜铬细胞瘤/副神经节瘤患者血NSE水平与临床特征的关系
Association of NSE level with clinical features in pheochromocytoma/paraganglioma
摘要
Abstract
Objective To study the relationship between serum neuron-specific enolase(NSE)and clinical features of pheochromocytoma/paraganglioma(PPGL).Methods Totally 501 PPGL patients diagnosed from January 2019 to December 2022 were divided into normal NSE group(NSE≤16.3 ng/mL)and elevated NSE group(NSE＞16.3 ng/mL).The clinical characteristics were compared between the two groups.Results Compared with normal NSE group,patients in the elevated NSE group had larger diameter in primary tumor(5.00 cm vs.4.60 cm),higher 24-hour urinary norepinephrine(NE)and 24-hour urinary dopamine(DA)levels,and a higher rate of metasta-sis(31.6%vs.13.7%)(P＜0.05).NSE level was positively correlated with the primary tumor size(r=0.131,P＜0.05),24-hour urinary NE level(r=0.195,P＜0.05)and 24-hour urinary DA level(r=0.119,P＜0.05).Conclusions The level of NSE is related to tumor size,secretion function and metastasis in PPGL patients.关键词
神经元特异性烯醇化酶/嗜铬细胞瘤/副神经节瘤/儿茶酚胺/转移Key words
neuron specific enolase/pheochromocytoma and paraganglioma/catecholamine/metastasis分类
医药卫生引用本文复制引用
李天翊,张文倩,陈映含,周玥,崔云英,王宇,童安莉..嗜铬细胞瘤/副神经节瘤患者血NSE水平与临床特征的关系[J].基础医学与临床,2024,44(4):533-538,6.基金项目
中央高水平医院临床科研业务费(2022-PUMCH-C-028) （2022-PUMCH-C-028）
中国医学科学院医学与健康科技创新工程(2021-I2M-C&T-B-002) （2021-I2M-C&T-B-002）
