基础医学与临床2024，Vol.44Issue(4)：553-557,5.DOI:10.16352/j.issn.1001-6325.2024.04.0553
年龄相关性黄斑变性的研究进展
Research advances on the age-related macular degeneration
摘要
Abstract
Age-related macular degeneration(AMD)is a serious threat to the visual health of the elderly,and the dysfunction of retinal pigment epithelial cells(RPE)is a significant etiology risk.Aging process leads to RPE repli-cation senescence,and some environment factors like light exposure and cigarette exposure may lead to RPE stress premature aging,and the decreased lysosomal digestion ability of senescent RPE cells may lead to the accumulation of lipofuscin,triggering the occurrence of early AMD.A series of homeostatic imbalances in aging retina,such as cell senescence-renewal imbalance,oxidative stress-antioxidant imbalance,chronic inflammatory-anti-inflammatory imbalance,intestinal barrier and intestinal microbiota imbalance and pro-angiogenesis-antiangiogenic imbalance all contribute to the development of AMD.关键词
年龄相关性黄斑变性/视网膜/视网膜色素上皮细胞/细胞衰老Key words
age-related macular degeneration(AMD)/retina/retinal pigment epithelial cells(RPE)/cellular senescence分类
医药卫生引用本文复制引用
魏丹丹,宋宇涵,王淇,宿树兰,朱悦,段金廒..年龄相关性黄斑变性的研究进展[J].基础医学与临床,2024,44(4):553-557,5.基金项目
国家自然科学基金(82173965,U21A20408) （82173965,U21A20408）
江苏省研究生实践创新项目(SJCX22_0806,SJCX23_0768) （SJCX22_0806,SJCX23_0768）
国家中医药管理局高水平中医药重点学科建设项目(国中医药人教函[2023]85号) （国中医药人教函[2023]85号）
