福州市新型冠状病毒感染致重症的危险因素分析OA北大核心CSTPCD
Analysis of risk factors for severe illness caused by coronavirus disease 2019 in Fuzhou city
目的 探讨福州市新型冠状病毒(新冠病毒)感染致重症的危险因素,为新冠病毒感染重症的防控提供依据.方法 检索"中国疾病预防控制信息系统",选取发病日期为2023年1月1日-6月30日,现住址为福州市的新冠病毒感染确诊患者4081例,调查并分析患者的人口学特征、临床表现、既往病史等资料,采用logistic回归分析重症患者的危险因素.结果 本组4081例新冠病毒感染确诊患者中,重症组671例,非重症组3410例.重症组的男性比例、年龄、现住址为社区的比例均高于非重症组,接种疫苗比例低于非重症组(59.02%vs.80.12%),差异有统计学意义(P＜0.001).在发病与就诊间隔时间方面,重症组为(7.27±4.85)d,长于非重症组的(4.37±2.54)d,差异有统计学意义(t=3.707,P=0.001).重症组首发症状为发热及呼吸困难/气促的比例高于非重症组,差异有统计学意义(P＜0.05).重症组的慢性肺部疾病史及心脑血管疾病史比例高于非重症组,差异有统计学意义(P＜0.001).多因素logistic回归分析结果显示:男性、年龄大、现住址归属为社区、未接种疫苗、发病与就诊间隔时间长、首发症状为发热、呼吸困难/气促、慢性肺部疾病史、心脑血管疾病史是新冠病毒感染重症患者的危险因素.重症组的治愈时间长于非重症组(P＜0.001).结论 性别、年龄、现住址归属、接种疫苗、发病与就诊间隔时间、发热、呼吸困难/气促、慢性肺部疾病史、心脑血管疾病史是导致重症的危险因素.
Objective To analyze the risk factors for severe illness caused by coronavirus disease 2019 in Fuzhou city.Methods The data of 4081 confirmed cases with current address in Fuzhou was collected from China Information System for Disease Control and Prevention from January 1 to June 30,2023.The epidemiological data of those cases was investigated such as the demographic characteristics,clinical manifestations and past medical history,etc.The risk factors of severe cases were analyzed by using the logistic regression.Results 4081 confirmed cases had been reported including 671 severe cases and 3410 non-severe cases.The demographic characteristics of severe cases,such as the proportion of male,age and current address in community were higher than that of non-severe cases,vaccination rate was lower than non-severe cases(59.02%vs.80.12%),the differences are statistically significant(P＜0.001).The clinical manifestations such as interval time between onset and visit(P=0.001),fever(P=0.002),difficulty in breathing/shortness of breath(P=0.001)were the factors related to severe illness.The past medical histories such as history of chronic lung disease,history of heart cerebrovascular disease of severe cases,were higher than that of non-severe cases(P＜0.001).Multivariate logistic regression showed that the male,the higher age,current address in community,no vaccination,the longer interval time between onset and visit,fever,difficulty in breathing/shortness of breath,the history of chronic lung disease,the history of heart cerebrovascular disease raised the risk of becoming severe cases.The healing time for severe cases was longer than that for non-severe cases(P＜0.001).Conclusion Sex,age,current address,vaccination,interval time between onset and visit,fever,difficulty in breathing/shortness of breath,history of chronic lung disease,and history of heart cerebrovascular disease are the influencing factors for severe illness.
郑霄雁;王依妹;官陈平;蒋莹;张晓阳
福州市疾病预防控制中心传染病防控科,福建福州 350004
基础医学
新型冠状病毒感染重症危险因素
coronavirus disease 2019severe caserisk factor
《解放军医学杂志》 2024 (003)
297-301 / 5
This work was supported by the Special Fund for Major Scientific Research on Health of Fujian(2021ZD0101),and the Science Technology Major Projects of Fuzhou(2020-Z-5) 福建省卫生健康重大科研专项基金(2021ZD0101);福州市科技重大项目(2020-Z-5)
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