江汉大学学报（自然科学版）2024，Vol.52Issue(2)：34-45,12.DOI:10.16389/j.cnki.cn42-1737/n.2024.02.005
基于SEER数据库分析婚姻状况对肝癌患者预后的影响
Analysis of Association Between Marital Status and Prognosis of Liver Cancer Patients Based on SEER Database
摘要
Abstract
Objective To investigate the influence of marital status on the prognosis of patients with liver cancer.Methods Information from 9759 patients was extracted from the SEER database,and univariate Log-rank and multivariate Cox risk scale models were used to evaluate the relationship between marital status and the prognosis of liver cancer.Results The death risk of divorced or separated patients(MHR = 1.24,95%CI(1.14,1.34),P<0.001),single patients(MHR = 1.22,95%CI(1.13,1.32),P<0.001),widowed patients(MHR = 1.21,95%CI(1.09,1.33),P<0.001)was higher than that of married patients,and the survival rate of married patients was higher than that of divorced,separated,single,and widowed patients.There were significant differences in the effects of marital status among HCC patients with different ages,races,tumor stages,and degrees of tumor differentiation,and there were statistically significant differences in the effects of marital status among the middle-aged group(χ2 = 99.6,P<0.001),White group(χ2 = 84.6,P<0.001),tumor stage I group(χ2 = 87.7,P<0.001),highly differentiated group(χ2 = 67.1,P<0.001)and moderately differentiated group(χ2 = 65.0,P<0.001).Conclusion Marital status can be an independent prognostic factor for patients with liver cancer to a certain extent,and the death risk coefficient of married patients with liver cancer is lower than that of patients with other marital statuses.关键词
肝癌/婚姻状况/预后/SEER数据库Key words
liver cancer/marital status/prognosis/SEER database分类
医药卫生引用本文复制引用
陈铭,陈恒,王东,徐金华,刘钰晨,柳昀熠..基于SEER数据库分析婚姻状况对肝癌患者预后的影响[J].江汉大学学报（自然科学版）,2024,52(2):34-45,12.基金项目
国家自然科学基金资助项目(81602642) （81602642）
湖北省教育厅指导项目(B2019233) （B2019233）
江汉大学基础性科研项目(2021jczx-002) （2021jczx-002）
江汉大学高层次人才培育项目(3015/06210046) （3015/06210046）
