检验医学与临床2024，Vol.21Issue(7)：870-874,879,6.DOI:10.3969/j.issn.1672-9455.2024.07.002
血清TNF-α、FS、Sp17Ab对子宫内膜异位症合并不孕症患者腹腔镜术后IVF-ET助孕妊娠结局的预测价值
Predictive value of serum TNF-α,FS and Sp17Ab levels for IVF-ET assisted pregnancy outcome after laparoscopic surgery in patients with endometriosis complicating infertility
摘要
Abstract
Objective To investigate the predictive value of serum tumor necrosis factor-α(TNF-α),fol-listatin(FS)and anti-sperm protein 17 antibody(Sp17Ab)for in vitro fertilization-embryo transfer(IVF-ET)assisted pregnancy outcome after laparoscopic surgery in the patients with endometriosis(EMT)complicating infertility.Methods A total of 157 patients with EMT complicating infertility receiving IVF-ET after laparo-scopic surgery in the Second Affiliated Hospital of Air Force Military Medical University from January 2020 to February 2022 were selected as the research subjects and divided into the pregnancy group and non-preg-nancy group according to the clinical pregnancy results.The levels of serum TNF-α,FS and Sp17Ab before IVF-ET were compared between the groups,the influencing factors of IVF-ET pregnancy outcome were ana-lyzed by the multivariate Logistic regression,the predictive value of serum TNF-α,FS and Sp17Ab on IVF-ET failure were analyzed by the receiver operating characteristic(ROC)curve.Results The levels of serum TNF-α,FS and Sp17Ab before IVF-ET assisted pregnancy in the pregnancy group were lower than those in the non-pregnancy group(P＜0.05).The proportion of the patients with ASRM stage Ⅲ-Ⅳ in the pregnancy group was lower than that in the non-pregnancy group,the EMT fertility index(EFI),basal luteinizing hormone(LH)and basic follicle-stimulating hormone(FSH)in the pregnancy group were higher than those in the non-pregnancy group,while the number of obtained oocytes and the number of transplantable embryos in the pregnancy group were more than those in the non-pregnancy group,and the differences were statistically sig-nificant(P＜0.05).The multivariate Logistic analysis results showed that the ASRM stage Ⅲ-Ⅳ and the increased levels of TNF-α,FS and Sp17Ab were the independent risk factors for IVF-ET(P＜0.05),while the increased EFI,the increased number of obtained oocytes and the increased number of transplantable embryos were the protective for factors IVF-ET(P＜0.05).The areas under the curve(AUC)of serum TNF-α,FS and Sp17Ab detection alone and their combined detection in predicting the IVF-ET failure were 0.691,0.775,0.688 and 0.862 respectively,the predictive efficiency of combined detection was better than that of each index alone(P＜0.05).Conclusion Serum TNF-α,FS and Sp17Ab are closely related to the clinical pregnancy out-come of IVF-ET assisted pregnancy after laparoscopic surgery in the patients with EMT complicating infertil-ity,the combine detection of TNF-α,FS and Sp17Ab has a high predictive value for the failure of IVF-ET as-sisted pregnancy after laparoscopic surgery in the patients with EMT complicating infertility.关键词
肿瘤坏死因子-α/卵泡抑素/抗精子蛋白17抗体/子宫内膜异位症/不孕症/腹腔镜手术/体外受精-胚胎移植/妊娠结局Key words
tumor necrosis factor-α/follistatin/anti-sperm protein 17 antibody/endometriosis/infertility/laparoscopic surgery/in vitro fertilization-embryo transfer/pregnancy outcome分类
医药卫生引用本文复制引用
邸曼,李雪峰,任洁,王鑫..血清TNF-α、FS、Sp17Ab对子宫内膜异位症合并不孕症患者腹腔镜术后IVF-ET助孕妊娠结局的预测价值[J].检验医学与临床,2024,21(7):870-874,879,6.基金项目
国家重点研发计划课题(2021YFC0907804). （2021YFC0907804）
