检验医学与临床2024，Vol.21Issue(7)：875-879,5.DOI:10.3969/j.issn.1672-9455.2024.07.003
血清髓过氧化物酶与脑小血管病患者认知障碍的相关性分析
Analysis on correlation between serum myeloperoxidase and cognitive impairment in patients with cerebral small vessel disease
摘要
Abstract
Objective To explore the correlation between serum myeloperoxidase(MPO)level and cogni-tive impairment in the patients with cerebral small vessel disease(CSVD).Methods A total of 125 patients with CSVD admitted and treated in this hospital from March 2021 to December 2022 were selected as the study group.At the same time,125 healthy people undergoing physical examination in this hospital were in-cluded as the control group.The mini-mental state examination(MMSE)and Montreal cognitive assessment(MoCA)were used to evaluate the cognitive function of the patients in the study group,and the patients were divided into the cognitive impairment group and cognitive normal group.Serum MPO level in all groups was detected.The correlation between serum MPO level and cognitive impairment in the patients with CSVD was analyzed by the Spearman correlation.The Logistic regression was used to analyze the influencing factors of cognitive impairment in CSVD patients.The receiver operating characteristic(ROC)curve was used to ana-lyze the predictive value of serum MPO for cognitive impairment.Results The incidence rate of cognitive im-pairment in 125 patients with CSVD was 38.40％(48/125).The serum MPO level in the study group was higher than that in the control group[(265.60±34.39)μg/L vs.(241.36±27.58)μg/L,P＜0.05].The lev-els of serum homocysteine(Hcy),high-sensitivity C-reactive protein(hs-CRP)and MPO in the cognitive im-pairment group were higher than those in the cognitive normal group,and the differences were statistically significant(P＜0.05).The levels of Hcy,hs-CRP and MPO were positively correlated with the cognitive im-pairment in CSVD patients(rs=0.430,0.345,0.448,P＜0.001).Logistic regression analysis results showed that serum Hcy,hs-CRP and MPO were the influencing factors for cognitive impairment occurrence in CSVD patients(P＜0.05).The ROC curve analysis results showed that the areas under the curves(AUC)of serum Hcy,hs-CRP and MPO levels alone and in combination for predicting cognitive impairment occurrence in CS-VD patients were 0.752,0.669,0.778 and 0.867 respectively.Conclusion The serum MPO level has the pre-dictive value for cognitive impairment occurrence in the patients with CSVD,and could serve as an auxiliary predictive indicator.The increase of serum MPO level suggests that CSVD patients have a high risk of cogni-tive impairment occurrence.关键词
脑小血管病/认知障碍/髓过氧化物酶/超敏C反应蛋白/同型半胱氨酸/预测价值Key words
cerebral small vessel disease/cognitive impairment/myeloperoxidase/high-sensitivity C-reactive protein/homocysteine/predictive value分类
医药卫生引用本文复制引用
孙美玉,张金洪,赵文义,王红,曹娟..血清髓过氧化物酶与脑小血管病患者认知障碍的相关性分析[J].检验医学与临床,2024,21(7):875-879,5.基金项目
河北省医学科学研究课题(20220311). （20220311）
