检验医学与临床2024，Vol.21Issue(7)：880-883,888,5.DOI:10.3969/j.issn.1672-9455.2024.07.004
AIDS患者感染侵袭性真菌的临床特征和危险因素研究
Clinical features and risk factors of invasive fungal infection in AIDS patients
摘要
Abstract
Objective To investigate the clinical features and risk factors of invasive fungal infection(IFI)in the patients with acquired immune deficiency syndrome(AIDS).Methods A total of 194 patients with AIDS visiting in this hospital from January 2021 to April 2023 were retrospectively analyzed.The patients were divided into the IFI group(107 cases)and non-IFI group(87 cases)according to whether complicating IFI.The distribution of funguses types in the IFI group was analyzed.The Logistic regression analysis was a-dopted to analyze the risk factors for AIDS complicating IFI.The receiver operating characteristic(ROC)curve was drawn to investigate the predictive value of those indexes for AIDS complicating IFI.Results The most infected fungus in the IFI group was Candida albicans,which accounted for 71.05％.The levels of CD4+T lymphocytes counts and serum albumin(ALB)in the IFI group were significantly lower than those in the non-IFI group(P＜0.001).The Logistic regression analysis showed that the CD4+T lymphocytes count de-crease and serum ALB level decrease were the independent risks for the patients with AID complicating IFI(P＜0.001).The ROC curve analysis results showed that the area under the curve of CD4+T lymphocytes count and serum ALB alone and combined for predicting AIDS complicating IFI were 0.954(95％CI:0.925-0.984),0.890(95％CI:0.844-0.935)and 0.960(95％CI:0.935-0.986)respectively.Conclusion The de-creases of CD4+T lymphocytes count and serum ALB level are the independent risk factors for the patients with AIDS complicating IFI.It is necessary for the clinic to pay attention to the high risk patients and take the intervention treatment in time.关键词
艾滋病/侵袭性真菌/危险因素/CD4+T淋巴细胞计数/清蛋白Key words
acquired immune deficiency syndrome/invasive fungus/risk factors/CD4+T lympho-cytes count/albumin分类
医药卫生引用本文复制引用
张雅婷,张媛媛,何柳,项杰..AIDS患者感染侵袭性真菌的临床特征和危险因素研究[J].检验医学与临床,2024,21(7):880-883,888,5.基金项目
湖北省卫生健康委员会基金项目(ZY2021M039). （ZY2021M039）
