检验医学与临床2024，Vol.21Issue(7)：884-888,5.DOI:10.3969/j.issn.1672-9455.2024.07.005
血清ANXA1、Hsp70、Hsp90α与局部晚期宫颈癌患者新辅助化疗疗效的关系分析
Analysis of relationship between serum ANXA1,Hsp70 and Hsp90α with efficacy of neoadjuvant chemotherapy in patients with locally advanced cervical cancer
摘要
Abstract
Objective To investigate the relationship between serum annexin A1(ANXA1),heat shock protein 70(Hsp70)and heat shock protein 90α(Hsp90α)with the efficacy of neoadjuvant chemotherapy(NACT)in the patients with locally advanced cervical cancer(LACC).Methods A total of 157 patients with LACC treated with NACT in this hospital from January 2020 to January 2023 were selected as the study sub-jects and divided into the effective group and ineffective group according to the effect of NACT.The levels of serum ANXA1,Hsp70 and Hsp90α before chemotherapy were compared between the two groups,the influen-cing factors of NACT efficacy were analyzed by the multivariate Logistics regression.The predictive value of serum ANXA1,Hsp70 and Hsp90α for NACT ineffectiveness in the patients with LACC was analyzed by the receiver operating characteristic(ROC)curve.Results The serum ANXA1 level in the effective group(126 cases)was higher than that in the ineffective group(31 cases),the serum Hsp70 and Hsp90α levels were low-er than those in the ineffective group,and the differences between two groups were statistically significant(P＜0.05).The univariate analysis showed that the proportion of the patients with Federation International of Gynecology and Obstetrics(FIGO)stage Ⅱ A2,proportion of the patients with low/undifferentiation,pro-portion of the patients with lymph node metastasis and CA125 and CA199 levels before chemotherapy in the effective group were lower than those in the ineffective group,and the differences were statistically significant(P＞0.05).The multivariate Logistics regression analysis showed that serum Hsp70 level increase,serum Hsp90α level increase,FIGO stage Ⅱ A2 and CA199 level increase were the independent risk factors for the ef-ficacy of NACT in the patients with LACC,and the ANXA1 level increase was a protective factor(P＜0.05).The area under the curve(AUC)of serum ANXA1,Hsp70,Hsp90α and the 3-indicator combined detection for predicting the NACT ineffective in the patients with LACC were 0.836,0.789,0.717 and 0.941 respec-tively.Conclusion Serum ANXA1,Hsp70 and Hsp90α are related to the efficacy of NACT in the patients with LACC,the combine detection of the three indicators has a high predictive value for the efficacy of NACT in the patients with LACC.关键词
局部晚期宫颈癌/膜联蛋白A1/热休克蛋白70/热休克蛋白90α/新辅助化疗/预测价值Key words
locally advanced cervical cancer/annexin A1/heat shock protein 70/heat shock protein 90α/neoadjuvant chemotherapy/predictive value分类
医药卫生引用本文复制引用
张慧雅,李慧娟..血清ANXA1、Hsp70、Hsp90α与局部晚期宫颈癌患者新辅助化疗疗效的关系分析[J].检验医学与临床,2024,21(7):884-888,5.基金项目
陕西省科技计划青年项目(2021JQ-727). （2021JQ-727）
