检验医学与临床2024，Vol.21Issue(7)：895-899,5.DOI:10.3969/j.issn.1672-9455.2024.07.007
常见自身免疫性疾病患者血清25-羟维生素D水平的差异分析
Differential analysis of serum 25-hydroxyvitamin D levels in patients with common autoimmune diseases
张彪 1曾丽娥 1卢鑫鑫 2黄肖利 1陈少婷 1梅端容 1江华1
作者信息
- 1. 福建医科大学省立临床医学院/福建省立医院检验科,福建福州 350001
- 2. 厦门大学附属中山医院检验科,福建厦门 361001
- 折叠
摘要
Abstract
Objective To analyze the difference of serum 25-hydroxyvitamin D[25(OH)D]levels in com-mon autoimmune diseases and its correlation with other laboratory indicators.Methods A total of 229 pa-tients with autoimmune diseases in the department of rheumatology and immunology in Fujian Provincial Hospital from September 2022 to April 2023 were selected as the experimental group,including 58 cases of systemic lupus erythematosus(SLE),45 cases of rheumatoid arthritis(RA),37 cases of Sjogren's syndrome(SS),60 cases of ankylosing spondylitis(AS),14 cases of dermatomyositis(DM)and 15 cases of systemic sclerosis(SSc).Twenty-nine healthy subjects undergoing physical examination during the same period were selected as the control group.Serum samples were collected,and the 25(OH)D levels in serum samples were de-tected by high performance liquid chromatography-tandem mass spectrometry.The differences of 25(OH)D2,25(OH)D3 and total 25(OH)D levels in the patients with common autoimmune diseases were analyzed.The correla-tion between the total 25(OH)D level and other laboratory indicators was analyzed.Results The proportion of deficient or insufficient serum total 25(OH)D level in the experimental group was generally higher than that in the control group.The 25(OH)D3 and total 25(OH)D levels in the experimental group were lower than those in the control group with statistical difference(P＜0.05).There were significant differences in the lev-els of 25(OH)D3 and total 25(OH)D among the disease subgroups in the experimental group(P＜0.05).In the comparison among all disease subgroups in the experimental group,the 25(OH)D3 and total 25(OH)D levels in the SLE group were the lowest and the difference was statistically significant compared with the SS group(P＜0.05).The 25(OH)D3 and total 25(OH)D levels in the female patients were lower than those in the male patients with statistical difference(P＜0.05).The serum 25(OH)D total level in the SLE group was negatively correlated with erythrocyte sedimentation rate(ESR),creatinine(CREA)and urea nitrogen(BUN)(P＜0.05),which in the RA group was negatively correlated with rheumatoid factor(RF)(P＜0.05),and which in the DM group was negatively correlated with ESR(P＜0.05).Conclusion The patients with autoimmune diseases are usually manifested as vitamin D deficiency or insufficiency,moreover the sex difference exists.In the patients with different autoimmune diseases,serum total 25(OH)D level shows differ-ent correlations with ESR,CREA,BUN and RF.关键词
自身免疫性疾病/25-羟维生素D/相关性/系统性红斑狼疮/类风湿关节炎/干燥综合征Key words
autoimmune disease/25-hydroxyvitamin D/correlation/systemic lupus erythematosus/rheumatoid arthritis/Sjogren's syndrome分类
医药卫生引用本文复制引用
张彪,曾丽娥,卢鑫鑫,黄肖利,陈少婷,梅端容,江华..常见自身免疫性疾病患者血清25-羟维生素D水平的差异分析[J].检验医学与临床,2024,21(7):895-899,5.
