摘要
Abstract
Objective To investigate the relationship between the levels of serum pentameric protein 3(PTX3)and soluble tumor necrosis factor like weak inducer of apoptosis(sTWEAK)with nonalcoholic fatty liver disease(NAFLD)in the patients with type 2 diabetes mellitus(T2DM).Methods One hundred and fif-ty-two patients with newly diagnosed T2DM in the General Hospital of Northern Theater Command were se-lected as the research subjects and were divided into the NAFLD group(92 cases)and non-NAFLD group(60 cases)according to whether complicating NAFLD.According to the results of liver ultrasound examination,the patients with NAFLD were divided into the mild group,moderate group and severe group.Other 35 healthy individuals were selected as the controls(control group).The enzyme-linked immunosorbent assay was used to detect the serum PTX3 and sTWEAK levels.The Pearson correlation method was used to analyze the relationship between PTX3 and sTWEAK with total cholesterol(TC),triacylglycerol(TG),low-density lipoprotein cholesterol(LDL-C),high-density lipoprotein cholesterol(HDL-C),fasting blood sugar(FPG),glycated hemoglobin(HbA1c)and insulin resistance index(HOMA-IR).The influencing factors of T2DM complicating NAFLD were analyzed by using Logistic regression.The value of PTX3 and sTWEAK in predic-ting the occurrence of NAFLD was analyzed by using the receiver operating characteristic(ROC)curve,and the area under the curve(AUC)was calculated.The levels of serum PTX3 and sTWEAK were compared a-mong the mild group,moderate group and severe group.Results Compared with the control group,the levels of serum PTX3 and sTWEAK in the NAFLD group and non-NAFLD group were higher(P＜0.05).Com-pared with the non-NAFLD group,the levels of serum PTX3 and sTWEAK in the NAFLD group were higher(P＜0.05).BMI(OR=3.387),TG(OR=1.958),HOMA-IR(OR=3.040),PTX3(OR=4.836)and sTWEAK(OR=4.133)were the influencing factors of T2DM complicating NAFLD(P＜0.05).Serum PTX3 level was positively correlated with BMI,LDL-C,FPG,HbA1c and HOMA-IR(P＜0.05),and negative-ly correlated with HDL-C(P＜0.05).Serum sTWEAK level was positively correlated with LDL-C,FPG,and HOMA-IR,respectively(P＜0.05).AUC of serum PTX3 and sTWEAK in predicting NAFLD occurrence in the patients with T2DM was 0.873 and 0.821 respectively.The combination of the two indicators could in-crease AUC to 0.915.There was a statistical difference in the serum PTX3 and sTWEAK levels among the mild group,moderate group and severe group(P＜0.05).The more severe the condition,the higher the serum PTX3 and sTWEAK levels.Conclusion PTX3 and sTWEAK are the influencing factors for the occurrence of NAFLD in the patients with T2DM,moreover the higher the levels of serum PTX3 and sTWEAK,the more severe the condition of NAFLD.关键词
2型糖尿病/正五聚蛋白3/可溶性肿瘤坏死因子样凋亡弱诱导因子/非酒精性脂肪性肝病/总胆固醇/甘油三酯/低密度脂蛋白胆固醇Key words
type 2 diabetes/pentameric protein 3/soluble tumor necrosis factor like weak inducer of apoptosis/nonalcoholic fatty liver disease/total cholesterol/triacylglycerol/low density lipoprotein cholesterol分类
医药卫生
