检验医学与临床2024，Vol.21Issue(7)：918-922,5.DOI:10.3969/j.issn.1672-9455.2024.07.012
青少年近视患者近视程度与角膜生物力学参数及视网膜微血管指标的相关性分析
Analysis on correlation between myopia degree with corneal biomechanics parameter and retinal microvasculature indicators in adolescents with myopia
摘要
Abstract
Objective To investigate the correlation between the myopia degree with corneal biomechanics parameter and retinal microvasculature indicators in adolescents with myopia.Methods A total of 171 adoles-cent patients with myopia(342 eyes)visiting in the department of ophthalmology in this hospital from May 2022 to June 2023 were selected as the study subjects and divided into the low degree group(51 cases,102 eyes),moderate group(67 cases,134 eyes)and high degree group(53 cases,106 eyes)according to the equiva-lent spherical lens(SE).Fifty healthy individuals(100 eyes)undergoing physical examination in this hospital during the same period were selected as the control group.The correlation between SE with corneal biome-chanics parameter,retinal microvessel and macular blood flow indicators was analyzed.Results The correla-tion analysis results showed that the corneal hysteresis(CH)quantity was positively correlated with SE(P＜0.05);There was no significant correlation between corneal resistance factor(CRF)and SE(P＞0.05).The overall and superficial capillary plexus(SCP)vascular density in the macular area and inner ring of the retina was positively correlated with SE(P＜0.05).There was no significant correlation between SCP vascular den-sity and SE in the central fovea and outer ring of the macular region(P＞0.05).The vascular density of the deep capillary plexus(DCP)in the macular area and outer ring of the retina was positively correlated with SE(P＜0.05).There was no significant correlation between the vascular density of DCP in the central fovea and inner ring of the macular region and SE(P＞0.05).The superficial capillary plexus blood flow density(SVD),deep capillary plexus blood flow density(DVD),and central foveal avascular zone(FAZ)area in the macular area of the retina were positively correlated with SE(P＜0.05).Conclusion For adolescent patients with myopia,with the degree of myopia increase,the lower the corneal viscoelasticity and hardness,and the lower the retinal microvascular density in the macular area.H owever,the change of related parameters such as FAZ area is still controversial.The hierarchical quantitative detection of retina by optical coherence tomo-graphy angiography is of great significance for clinical diagnosis and treatment.关键词
近视/角膜生物力学/视网膜/黄斑/青少年Key words
myopia/corneal biomechanics/retina/macula flava/adolescents分类
临床医学引用本文复制引用
贾娜,符俊达,朱海萍,杨婉晨,孙轶军..青少年近视患者近视程度与角膜生物力学参数及视网膜微血管指标的相关性分析[J].检验医学与临床,2024,21(7):918-922,5.基金项目
河北省秦皇岛市科学技术研究与发展计划项目(202301A190). （202301A190）
