检验医学与临床2024，Vol.21Issue(7)：923-928,6.DOI:10.3969/j.issn.1672-9455.2024.07.013
腹膜透析相关性腹膜炎患者肠道菌群变化研究
Intestinal flora change in patients with peritoneal dialysis-related peritonitis
摘要
Abstract
Objective To investigate the association of intestinal flora disturbance and peritoneal dialysis-related peritonitis.Methods A total of 85 patients with regular peritoneal dialysis in this hospital from Janu-ary 2022 to December 2022 were collected and divided into the peritonitis group(40 cases)and non-peritonitis group(45 cases)according to whether peritoneal dialysis-related peritonitis occurring.The differences in the distribution of intestinal flora were compared between the two groups and the correlation between the intesti-nal flora disturbance and the occurrence of peritonitis was analyzed.Results The abundances of Eubacterium,Roseburia,Absiella and Lachnospiraceae in the peritonitis group were higher than those in the non-peritonitis group,while the abundances of Akkermansia,Prevotellaceae,Enterococcus and Sarteria were lower than those in the non-peritonitis group,and the differences were statistically significant(P＜0.05).The correlation anal-ysis demonstrated that the abundances of harmful bacteria in the intestinal tract was positively correlated with the blood indicators of peritonitis such as white blood cell count,neutrophil percentage and C-reactive protein(P＜0.05),while the abundances of beneficial bacteria in the intestinal tract were negatively correlated white blood cell count,neutrophil percentage and C-reactive protein.Additionally,the fecal short-chain fatty acids(acetic acid,propionic acid,and butyric acid)levels were negatively correlated with white blood cell count,neutrophil percentage and C-reactive protein(P＜0.05)and positively correlated with the abundances of en-terococcus,Ackermannia,Sarteria and Prevotellaceae(P＜0.05).Conclusion The occurrence of peritoneal di-alysis-related peritonitis is closely related with intestinal flora disturbance of the patients,and detecting the in-testinal flora and fecal short-chain fatty acids has a certain assisted detection value for peritoneal dialysis-asso-ciated peritonitis.关键词
腹膜透析/腹膜炎/肠道菌群/炎症因子/短链脂肪酸Key words
peritoneal dialysis/peritonitis/intestinal flora/inflammatory cytokines/short-chain fatty acids分类
医药卫生引用本文复制引用
何阶德,黄朦,黄存军,刘红玉,梁航..腹膜透析相关性腹膜炎患者肠道菌群变化研究[J].检验医学与临床,2024,21(7):923-928,6.基金项目
湘南学院校级课题医院联合项目(2021XJ94). （2021XJ94）
